| 2021-04-18 | Gamba OsakavShimizu S-PulseJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-04-18 | RegensburgvHeidenheim2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-04-18 | Club BruggevMouscronPro League · Belgium | 4–2 | Pro League · Belgium |
| 2021-04-18 | FCSBvFC BotosaniSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-04-18 | NacionalvPortoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-04-18 | BrestvLensLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-04-18 | BrondbyvAarhusSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-04-18 | StandardvBeerschot VAPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-04-18 | Spartak MoscowvUfaPremier League · Russia | 0–3 | Premier League · Russia |
| 2021-04-18 | CadizvCeltaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-04-18 | FC ArgesvPoli IasiSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-04-18 | Oud-Heverlee LeuvenvWaasland-BeverenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-04-18 | GetafevReal MadridLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-04-18 | BuyuksehyrvFenerbahceSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-04-18 | Nagoya GrampusvSagan TosuJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-04-18 | CartagenavTenerifeLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-04-18 | Estudiantes L.P.vGimnasia L.P.Copa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-18 | HorsensvLyngbySuperliga · Denmark | 1–3 | Superliga · Denmark |
| 2021-04-18 | Columbus CrewvPhiladelphia UnionMLS · United States | 0–0 | MLS · United States |
| 2021-04-18 | KortrijkvMechelenPro League · Belgium | 1–4 | Pro League · Belgium |
| 2021-04-18 | UralvRubin KazanPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-04-18 | ArsenalvFulhamPremier League · England | 1–1 | Premier League · England |
| 2021-04-18 | Nashville SCvFC CincinnatiMLS · United States | 2–2 | MLS · United States |
| 2021-04-18 | AtalantavJuventusSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-04-18 | FamalicaovPortimonensePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-04-18 | Inter MiamivLos Angeles GalaxyMLS · United States | 2–3 | MLS · United States |
| 2021-04-18 | Young BoysvLuganoSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2021-04-18 | Paris SGvSt EtienneLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-04-18 | Cerezo OsakavUrawa RedsJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-04-18 | SalzburgvLASKBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-04-18 | SK RapidvSturm GrazBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-04-18 | OstersundsvOrebroAllsvenskan · Sweden | 5–0 | Allsvenskan · Sweden |
| 2021-04-18 | Man UnitedvBurnleyPremier League · England | 3–1 | Premier League · England |
| 2021-04-18 | Arsenal TulavTambovPremier League · Russia | 4–0 | Premier League · Russia |
| 2021-04-18 | FC CopenhagenvNordsjaellandSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-04-17 | Newport CountyvCambridgeLeague Two · England | 0–1 | League Two · England |
| 2021-04-17 | AugsburgvBielefeldBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-04-17 | Lokomotiv MoscowvFK RostovPremier League · Russia | 4–1 | Premier League · Russia |
| 2021-04-17 | MiddlesbroughvQPRChampionship · England | 1–2 | Championship · England |
| 2021-04-17 | AFC WimbledonvSwindonLeague One · England | 4–1 | League One · England |
| 2021-04-17 | SochauxvPau FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-17 | Houston DynamovSan Jose EarthquakesMLS · United States | 2–1 | MLS · United States |
| 2021-04-17 | HullvFleetwood TownLeague One · England | 2–1 | League One · England |
| 2021-04-17 | Edinburgh CityvQueens ParkLeague Two · Scotland | 2–3 | League Two · Scotland |
| 2021-04-17 | RiedvAltachBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-04-17 | DunkerquevGrenobleLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-17 | CrotonevUdineseSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-04-17 | BenficavGil VicentePrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-04-17 | YeovilvBoreham WoodNational League · England | 1–0 | National League · England |
| 2021-04-17 | OFI CretevAtromitosSuper League · Greece | 1–1 | Super League · Greece |