| 2022-04-03 | ZwollevGo Ahead EaglesEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-04-03 | StrasbourgvLensLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-04-03 | BirminghamvWest BromChampionship · England | 1–0 | Championship · England |
| 2022-04-03 | TottenhamvNewcastlePremier League · England | 5–1 | Premier League · England |
| 2022-04-03 | BrondbyvRanders FCSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2022-04-03 | MoreirensevGuimaraesPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-04-03 | Cruz AzulvAtlasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-04-03 | Club LeonvQueretaroLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-04-03 | Newells Old BoysvPlatenseCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-03 | OddvTromsoEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2022-04-03 | KonyasporvGoztepSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2022-04-03 | Wolfsberger ACvSturm GrazBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2022-04-03 | AlanyasporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-04-03 | LausannevServetteSuper League · Switzerland | 4–1 | Super League · Switzerland |
| 2022-04-03 | Sparta RotterdamvHeerenveenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-04-03 | AugsburgvWolfsburgBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-04-03 | AtalantavNapoliSerie A · Italy | 1–3 | Serie A · Italy |
| 2022-04-03 | Orlando CityvLos Angeles FCMLS · United States | 2–4 | MLS · United States |
| 2022-04-03 | AalesundvKristiansundEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2022-04-03 | SampdoriavRomaSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-04-03 | Colorado RapidsvReal Salt LakeMLS · United States | 1–1 | MLS · United States |
| 2022-04-03 | CSKA MoscowvUralPremier League · Russia | 2–2 | Premier League · Russia |
| 2022-04-03 | HaugesundvSandefjordEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2022-04-03 | CartagenavOviedoLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-04-03 | M'gladbachvMainzBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-04-03 | KrasnodarvDynamo MoscowPremier League · Russia | 0–1 | Premier League · Russia |
| 2022-04-03 | Sarpsborg 08vVikingEliteserien · Norway | 0–1 | Eliteserien · Norway |
| 2022-04-03 | CrotonevPerugiaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-04-03 | JervvStromsgodsetEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2022-04-03 | HeidenheimvNurnberg2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2022-04-03 | UdinesevCagliariSerie A · Italy | 5–1 | Serie A · Italy |
| 2022-04-03 | GoteborgvVarnamoAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2022-04-03 | Boca JuniorsvArsenal SarandiCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-03 | ComovMonzaSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-04-03 | Vancouver WhitecapsvSporting Kansas CityMLS · United States | 1–0 | MLS · United States |
| 2022-04-03 | GranadavVallecanoLa Liga · Spain | 2–2 | La Liga · Spain |
| 2022-04-03 | BresciavVicenzaSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-04-03 | NorrkopingvVarbergAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2022-04-03 | San LorenzovAtl. TucumanCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-03 | LuzernvLuganoSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2022-04-03 | Austria ViennavA. KlagenfurtBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2022-04-03 | HuescavAlmeriaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-04-03 | Termalica B-B.vRadomiak RadomEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-04-03 | StandardvSt. GilloisePro League · Belgium | 1–3 | Pro League · Belgium |
| 2022-04-03 | JagielloniavZaglebieEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2022-04-03 | Queens ParkvCove RangersLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-04-03 | FiorentinavEmpoliSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-04-03 | ArisvGianninaSuper League · Greece | 0–0 | Super League · Greece |
| 2022-04-03 | MaritimovTondelaPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2022-04-03 | ClermontvNantesLigue 1 · France | 2–3 | Ligue 1 · France |