| 2021-04-18 | DijonvNiceLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-04-18 | SiriusvHalmstadAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-04-18 | BolognavSpeziaSerie A · Italy | 4–1 | Serie A · Italy |
| 2021-04-18 | MilanvGenoaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-04-18 | Stal MielecvZaglebieEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-04-18 | DjurgardenvNorrkopingAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-04-18 | OdensevSonderjyskeSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-04-18 | DegerforsvKalmarAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-04-18 | OsasunavElcheLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-04-18 | Guadalajara ChivasvClub TijuanaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-04-18 | SochivCSKA MoscowPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-04-18 | Kawasaki FrontalevSanfrecce HiroshimaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-04-18 | SociedadvSevillaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-04-18 | DC UnitedvNew York CityMLS · United States | 2–1 | MLS · United States |
| 2021-04-18 | OsnabruckvFortuna Dusseldorf2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-04-18 | BetisvValenciaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-04-18 | ReimsvMetzLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-04-18 | St TruidenvAnderlechtPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-04-18 | Club AmericavCruz AzulLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-04-18 | GaziantepvKasimpasaSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-04-18 | IndependientevDefensa y JusticiaCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-18 | NapolivInterSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-04-18 | Chicago FirevNew England RevolutionMLS · United States | 2–2 | MLS · United States |
| 2021-04-18 | CFR ClujvAcademica ClinceniSuperliga · Romania | 3–0 | Superliga · Romania |
| 2021-04-18 | LausannevVaduzSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-04-18 | AEKvAsteras TripolisSuper League · Greece | 3–1 | Super League · Greece |
| 2021-04-18 | NimesvStrasbourgLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-04-18 | New York Red BullsvSporting Kansas CityMLS · United States | 1–2 | MLS · United States |
| 2021-04-18 | HackenvMalmo FFAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-04-18 | CoventryvBarnsleyChampionship · England | 2–0 | Championship · England |
| 2021-04-18 | AlavesvHuescaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-04-18 | DortmundvWerder BremenBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2021-04-18 | UNAM PumasvTigres UANLLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-04-18 | BochumvHannover2. Bundesliga · Germany | 4–3 | 2. Bundesliga · Germany |
| 2021-04-18 | LaziovBeneventoSerie A · Italy | 5–3 | Serie A · Italy |
| 2021-04-18 | Ath MadridvEibarLa Liga · Spain | 5–0 | La Liga · Spain |
| 2021-04-18 | LevantevVillarrealLa Liga · Spain | 1–5 | La Liga · Spain |
| 2021-04-18 | NantesvLyonLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-04-18 | PAOKvOlympiakosSuper League · Greece | 2–0 | Super League · Greece |
| 2021-04-18 | WaregemvGentPro League · Belgium | 2–7 | Pro League · Belgium |
| 2021-04-18 | BaselvServetteSuper League · Switzerland | 5–0 | Super League · Switzerland |
| 2021-04-18 | Wolfsberger ACvTirolBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-04-18 | LogronesvVallecanoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-04-18 | FC DallasvColorado RapidsMLS · United States | 0–0 | MLS · United States |
| 2021-04-18 | PanathinaikosvArisSuper League · Greece | 1–2 | Super League · Greece |
| 2021-04-18 | Newells Old BoysvPatronatoCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-18 | Bordeauxv MonacoLigue 1 · France | 0–3 | Ligue 1 · France |
| 2021-04-18 | AlbacetevMirandesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-04-18 | LegiavCracoviaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-04-18 | TorinovRomaSerie A · Italy | 3–1 | Serie A · Italy |