| 2022-04-05 | HamburgvErzgebirge Aue2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2022-04-05 | Sligo RoversvBohemiansPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2022-04-05 | WrexhamvBarnetNational League · England | 6–0 | National League · England |
| 2022-04-05 | HalifaxvSolihullNational League · England | 0–0 | National League · England |
| 2022-04-05 | ReadingvStokeChampionship · England | 2–1 | Championship · England |
| 2022-04-05 | Kings LynnvBromleyNational League · England | 1–0 | National League · England |
| 2022-04-05 | RegginavBeneventoSerie B · Italy | 0–3 | Serie B · Italy |
| 2022-04-05 | SalfordvPort ValeLeague Two · England | 0–1 | League Two · England |
| 2022-04-04 | MidtjyllandvSilkeborgSuperliga · Denmark | 3–2 | Superliga · Denmark |
| 2022-04-04 | TigrevRosario CentralCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-04 | VeronavGenoaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-04-04 | PortovSanta ClaraPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2022-04-04 | BuyuksehyrvYeni MalatyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2022-04-04 | ElfsborgvMjallbyAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2022-04-04 | DjurgardenvDegerforsAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2022-04-04 | Tigres UANLvClub TijuanaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-04-04 | UC DublinvDerry CityPremier Division · Ireland | 0–2 | Premier Division · Ireland |
| 2022-04-04 | Santos LagunavPachucaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2022-04-04 | Finn HarpsvDroghedaPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2022-04-04 | CFR ClujvFC ArgesSuperliga · Romania | 2–0 | Superliga · Romania |
| 2022-04-04 | Sepsi Sf. GheorghevAcademica ClinceniSuperliga · Romania | 6–0 | Superliga · Romania |
| 2022-04-04 | NancyvAjaccioLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-04-04 | SociedadvEspanolLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-04-04 | HataysporvAd. DemirsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-04-04 | LeganesvFuenlabradaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2022-04-04 | Wisla PlockvGornik Z.Ekstraklasa · Poland | 3–2 | Ekstraklasa · Poland |
| 2022-04-04 | Crystal PalacevArsenalPremier League · England | 3–0 | Premier League · England |
| 2022-04-04 | MilanvBolognaSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-04-03 | WislavPiast GliwiceEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2022-04-03 | Cercle BruggevGentPro League · Belgium | 2–2 | Pro League · Belgium |
| 2022-04-03 | San Jose EarthquakesvAustin FCMLS · United States | 2–2 | MLS · United States |
| 2022-04-03 | OlympiakosvAEKSuper League · Greece | 1–1 | Super League · Greece |
| 2022-04-03 | Portland TimbersvLos Angeles GalaxyMLS · United States | 1–3 | MLS · United States |
| 2022-04-03 | BarcelonavSevillaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-04-03 | Paris SGvLorientLigue 1 · France | 5–1 | Ligue 1 · France |
| 2022-04-03 | KalmarvMalmo FFAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2022-04-03 | FCSBvUniv. CraiovaSuperliga · Romania | 0–2 | Superliga · Romania |
| 2022-04-03 | PanathinaikosvPAOKSuper League · Greece | 2–1 | Super League · Greece |
| 2022-04-03 | SiriusvSundsvallAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2022-04-03 | TroyesvReimsLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-04-03 | AnderlechtvCharleroiPro League · Belgium | 4–0 | Pro League · Belgium |
| 2022-04-03 | Bodo/GlimtvRosenborgEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2022-04-03 | SochivZenitPremier League · Russia | 0–0 | Premier League · Russia |
| 2022-04-03 | KarlsruhevFortuna Dusseldorf2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-03 | Inter MiamivHouston DynamoMLS · United States | 1–3 | MLS · United States |
| 2022-04-03 | Metzv MonacoLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-04-03 | Ath BilbaovElcheLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-04-03 | Minnesota UnitedvSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2022-04-03 | AarhusvVejleSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2022-04-03 | NecaxavClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |