| 2021-04-20 | AldershotvKings LynnNational League · England | 1–1 | National League · England |
| 2021-04-20 | WokingvTorquayNational League · England | 0–2 | National League · England |
| 2021-04-20 | Airdrie UtdvEast FifeLeague One · Scotland | 2–0 | League One · Scotland |
| 2021-04-20 | ForfarvClydeLeague One · Scotland | 1–3 | League One · Scotland |
| 2021-04-20 | MontrosevCove RangersLeague One · Scotland | 1–0 | League One · Scotland |
| 2021-04-20 | Austria ViennavRiedBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-04-20 | BoltonvCarlisleLeague Two · England | 1–0 | League Two · England |
| 2021-04-20 | Leyton OrientvCambridgeLeague Two · England | 2–4 | League Two · England |
| 2021-04-20 | LongfordvFinn HarpsPremier Division · Ireland | 0–0 | Premier Division · Ireland |
| 2021-04-20 | Pau FCvAuxerreLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-04-20 | Forest GreenvExeterLeague Two · England | 0–0 | League Two · England |
| 2021-04-20 | Club LeonvJuarezLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-04-20 | St. PatricksvWaterfordPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-04-20 | Slask WroclawvPodbeskidzieEkstraklasa · Poland | 4–3 | Ekstraklasa · Poland |
| 2021-04-20 | CaenvDunkerqueLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-20 | Lech PoznanvLechia GdanskEkstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2021-04-20 | Wurzburger KickersvDarmstadt2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2021-04-20 | Guangzhou FCvGuangzhou CitySuper League · China | 2–2 | Super League · China |
| 2021-04-20 | NorwichvWatfordChampionship · England | 0–1 | Championship · England |
| 2021-04-20 | PeterborovGillinghamLeague One · England | 0–1 | League One · England |
| 2021-04-20 | PeterheadvFalkirkLeague One · Scotland | 1–0 | League One · Scotland |
| 2021-04-20 | VeronavFiorentinaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-04-20 | Greuther FurthvBraunschweig2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-04-20 | NancyvAjaccioLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-04-20 | BarrowvPort ValeLeague Two · England | 0–2 | League Two · England |
| 2021-04-20 | RizesporvKonyasporSüper Lig · Turkey | 5–3 | Süper Lig · Turkey |
| 2021-04-20 | Din. BucurestivUTA AradSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-04-20 | SivassporvBesiktasSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-20 | KaragumrukvGoztepSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-20 | Warta PoznanvRakowEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-04-20 | Newport CountyvCrawley TownLeague Two · England | 2–0 | League Two · England |
| 2021-04-20 | Pogon SzczecinvGornik Z.Ekstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-04-20 | AccringtonvDoncasterLeague One · England | 2–1 | League One · England |
| 2021-04-20 | PrestonvDerbyChampionship · England | 3–0 | Championship · England |
| 2021-04-19 | Santos LagunavTolucaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-04-19 | LeedsvLiverpoolPremier League · England | 1–1 | Premier League · England |
| 2021-04-19 | VarbergvElfsborgAllsvenskan · Sweden | 1–3 | Allsvenskan · Sweden |
| 2021-04-19 | AlmeriavEspanolLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-04-19 | Colon Santa FEvGodoy CruzCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2021-04-19 | Randers FCvMidtjyllandSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2021-04-19 | LeganesvPonferradinaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-04-19 | BanfieldvPlatenseCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-19 | Vancouver WhitecapsvPortland TimbersMLS · United States | 1–0 | MLS · United States |
| 2021-04-19 | GoteborgvAIKAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-04-19 | LamiavLarisaSuper League · Greece | 0–0 | Super League · Greece |
| 2021-04-19 | MonterreyvPachucaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-04-18 | Arsenal SarandivRacing ClubCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-18 | OostendevCercle BruggePro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-04-18 | Wisla PlockvJagielloniaEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-04-18 | RotherhamvBirminghamChampionship · England | 0–1 | Championship · England |