| 2022-04-08 | Fortuna DusseldorfvHansa Rostock2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-04-08 | AtlasvNecaxaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-04-08 | LahtivVPSVeikkausliiga · Finland | 0–5 | Veikkausliiga · Finland |
| 2022-04-08 | AalborgvRanders FCSuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2022-04-08 | SJKvHJKVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2022-04-08 | ShelbournevShamrock RoversPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2022-04-08 | RegensburgvIngolstadt2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-08 | SevillavGranadaLa Liga · Spain | 4–2 | La Liga · Spain |
| 2022-04-07 | HonkavHakaVeikkausliiga · Finland | 3–2 | Veikkausliiga · Finland |
| 2022-04-07 | TolucavMonterreyLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2022-04-07 | Club TijuanavAtl. San LuisLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-04-06 | Urawa RedsvShimizu S-PulseJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-04-06 | MiddlesbroughvFulhamChampionship · England | 0–1 | Championship · England |
| 2022-04-06 | CittadellavPerugiaSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-04-06 | FK RostovvKrylya SovetovPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-04-06 | AugsburgvMainzBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-04-06 | Avispa FukuokavKashima AntlersJ1 League · Japan | 0–1 | J1 League · Japan |
| 2022-04-06 | DunfermlinevRaith RvsChampionship · Scotland | 2–0 | Championship · Scotland |
| 2022-04-06 | Nagoya GrampusvShonan BellmareJ1 League · Japan | 2–1 | J1 League · Japan |
| 2022-04-06 | VicenzavCrotoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-04-06 | IwatavKawasaki FrontaleJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-04-06 | ParmavComoSerie B · Italy | 4–3 | Serie B · Italy |
| 2022-04-06 | FC TokyovVissel KobeJ1 League · Japan | 3–1 | J1 League · Japan |
| 2022-04-06 | Sanfrecce HiroshimavYokohama F. MarinosJ1 League · Japan | 2–0 | J1 League · Japan |
| 2022-04-06 | KyotovGamba OsakaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-04-06 | West BromvBournemouthChampionship · England | 2–0 | Championship · England |
| 2022-04-06 | PisavBresciaSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-04-06 | Nott'm ForestvCoventryChampionship · England | 2–0 | Championship · England |
| 2022-04-06 | Sagan TosuvHokkaido Consadole SapporoJ1 League · Japan | 5–0 | J1 League · Japan |
| 2022-04-06 | MonzavAscoliSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-04-06 | BurnleyvEvertonPremier League · England | 3–2 | Premier League · England |
| 2022-04-05 | CambridgevWycombeLeague One · England | 1–4 | League One · England |
| 2022-04-05 | Milton Keynes DonsvCreweLeague One · England | 2–1 | League One · England |
| 2022-04-05 | WiganvAccringtonLeague One · England | 3–0 | League One · England |
| 2022-04-05 | SpalvCosenzaSerie B · Italy | 2–2 | Serie B · Italy |
| 2022-04-05 | Sheffield UnitedvQPRChampionship · England | 1–0 | Championship · England |
| 2022-04-05 | WealdstonevMaidenheadNational League · England | 0–0 | National League · England |
| 2022-04-05 | PrestonvBlackpoolChampionship · England | 1–0 | Championship · England |
| 2022-04-05 | PeterborovLutonChampionship · England | 1–1 | Championship · England |
| 2022-04-05 | CremonesevAlessandriaSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-04-05 | MillwallvSwanseaChampionship · England | 0–1 | Championship · England |
| 2022-04-05 | Cerezo OsakavKashiwa ReysolJ1 League · Japan | 0–1 | J1 League · Japan |
| 2022-04-05 | BoltonvPortsmouthLeague One · England | 1–1 | League One · England |
| 2022-04-05 | Fleetwood TownvLincolnLeague One · England | 1–1 | League One · England |
| 2022-04-05 | Dag and RedvBoreham WoodNational League · England | 0–0 | National League · England |
| 2022-04-05 | Forest GreenvMansfieldLeague Two · England | 1–0 | League Two · England |
| 2022-04-05 | TernanavLecceSerie B · Italy | 1–4 | Serie B · Italy |
| 2022-04-05 | PordenonevFrosinoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-04-05 | MorecambevOxfordLeague One · England | 2–1 | League One · England |
| 2022-04-05 | AFC WimbledonvCharltonLeague One · England | 1–1 | League One · England |