| 2016-04-03 | NijmegenvVitesseEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2016-04-03 | BanfieldvColon Santa FELiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2016-04-03 | Uniao MadeiravSetubalPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2016-04-03 | Sporting Kansas CityvReal Salt LakeMLS · United States | 1–2 | MLS · United States |
| 2016-04-03 | OdensevRanders FCSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2016-04-03 | OddvTromsoEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2016-04-03 | Poli IasivU CraiovaSuperliga · Romania | 3–0 | Superliga · Romania |
| 2016-04-03 | PanathinaikosvVeriaSuper League · Greece | 3–2 | Super League · Greece |
| 2016-04-03 | M'gladbachvHerthaBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2016-04-03 | NumanciavHuescaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2016-04-03 | ZaglebievPiast GliwiceEkstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2016-04-03 | AalesundvBrannEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2016-04-03 | PanioniosvPAOKSuper League · Greece | 3–1 | Super League · Greece |
| 2016-04-03 | GironavOsasunaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-04-03 | EibarvVillarrealLa Liga · Spain | 1–2 | La Liga · Spain |
| 2016-04-03 | LorientvLyonLigue 1 · France | 1–3 | Ligue 1 · France |
| 2016-04-03 | PatronatovRiver PlateLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2016-04-03 | IntervTorinoSerie A · Italy | 1–2 | Serie A · Italy |
| 2016-04-03 | HackenvElfsborgAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2016-04-03 | BuyuksehyrvMersin Idman YurduSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2016-04-03 | NovaravSalernitanaSerie B · Italy | 1–1 | Serie B · Italy |
| 2016-04-03 | PlataniasvXanthiSuper League · Greece | 3–1 | Super League · Greece |
| 2016-04-03 | Lokomotiv MoscowvRubin KazanPremier League · Russia | 1–0 | Premier League · Russia |
| 2016-04-03 | StromsgodsetvHaugesundEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2016-04-03 | LeicestervSouthamptonPremier League · England | 1–0 | Premier League · England |
| 2016-04-03 | SevillavSociedadLa Liga · Spain | 1–2 | La Liga · Spain |
| 2016-04-03 | MalagavEspanolLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-04-03 | Vancouver WhitecapsvLos Angeles GalaxyMLS · United States | 0–0 | MLS · United States |
| 2016-04-03 | AtalantavMilanSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-04-03 | BastiavMarseilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2016-04-03 | AIKvSundsvallAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2016-04-03 | GenoavFrosinoneSerie A · Italy | 4–0 | Serie A · Italy |
| 2016-04-03 | Ath BilbaovGranadaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-04-03 | IraklisvAsteras TripolisSuper League · Greece | 0–1 | Super League · Greece |
| 2016-04-03 | FC DallasvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2016-04-03 | RodavHeerenveenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2016-04-03 | EstorilvPacos FerreiraPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2016-04-03 | Man UnitedvEvertonPremier League · England | 1–0 | Premier League · England |
| 2016-04-03 | NantesvLilleLigue 1 · France | 0–3 | Ligue 1 · France |
| 2016-04-03 | San Jose EarthquakesvDC UnitedMLS · United States | 1–1 | MLS · United States |
| 2016-04-03 | OlympiakosvPanthrakikosSuper League · Greece | 4–0 | Super League · Greece |
| 2016-04-03 | UdinesevNapoliSerie A · Italy | 3–1 | Serie A · Italy |
| 2016-04-03 | FC CopenhagenvSonderjyskeSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2016-04-03 | SK RapidvSalzburgBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2016-04-03 | GimnasticvCordobaLa Liga 2 · Spain | 4–4 | La Liga 2 · Spain |
| 2016-04-03 | Defensa y JusticiavArsenal SarandiLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2016-04-03 | ChievovPalermoSerie A · Italy | 3–1 | Serie A · Italy |
| 2016-04-03 | Tigres UANLvAtlasLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2016-04-03 | San LorenzovBelgranoLiga Profesional · Argentina | 3–2 | Liga Profesional · Argentina |
| 2016-04-03 | TenerifevLugoLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |