| 2022-04-09 | Las PalmasvAmorebietaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-04-09 | Crawley TownvBarrowLeague Two · England | 1–0 | League Two · England |
| 2022-04-09 | FrosinonevCremoneseSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-04-09 | KaragumrukvKasimpasaSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2022-04-09 | Quevilly RouenvRodezLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-04-09 | Le HavrevDunkerqueLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-09 | ColchestervStevenageLeague Two · England | 0–2 | League Two · England |
| 2022-04-09 | BurtonvPlymouthLeague One · England | 0–0 | League One · England |
| 2022-04-09 | AntwerpvCercle BruggePro League · Belgium | 1–1 | Pro League · Belgium |
| 2022-04-09 | Finn HarpsvDerry CityPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2022-04-09 | UTA AradvFC Rapid BucurestiSuperliga · Romania | 0–2 | Superliga · Romania |
| 2022-04-09 | Real MadridvGetafeLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-04-09 | Sligo RoversvUC DublinPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2022-04-09 | DoncastervCreweLeague One · England | 2–0 | League One · England |
| 2022-04-09 | GillinghamvWycombeLeague One · England | 1–1 | League One · England |
| 2022-04-09 | ArsenalvBrightonPremier League · England | 1–2 | Premier League · England |
| 2022-04-09 | AldershotvBoreham WoodNational League · England | 2–1 | National League · England |
| 2022-04-09 | AyrvInverness CChampionship · Scotland | 2–2 | Championship · Scotland |
| 2022-04-09 | OxfordvSunderlandLeague One · England | 1–2 | League One · England |
| 2022-04-09 | Annan AthleticvCowdenbeathLeague Two · Scotland | 2–3 | League Two · Scotland |
| 2022-04-09 | FalkirkvCove RangersLeague One · Scotland | 0–2 | League One · Scotland |
| 2022-04-09 | SwindonvNewport CountyLeague Two · England | 0–1 | League Two · England |
| 2022-04-09 | ClermontvParis SGLigue 1 · France | 1–6 | Ligue 1 · France |
| 2022-04-09 | SalfordvHarrogateLeague Two · England | 2–0 | League Two · England |
| 2022-04-09 | HamiltonvArbroathChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-04-09 | MiddlesbroughvHullChampionship · England | 0–1 | Championship · England |
| 2022-04-09 | Edinburgh CityvForfarLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2022-04-09 | ScunthorpevMansfieldLeague Two · England | 0–4 | League Two · England |
| 2022-04-09 | NorthamptonvBradfordLeague Two · England | 0–0 | League Two · England |
| 2022-04-09 | Fleetwood TownvAccringtonLeague One · England | 1–2 | League One · England |
| 2022-04-09 | Inter TurkuvAC OuluVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2022-04-09 | DegerforsvHackenAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2022-04-09 | CagliarivJuventusSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-04-09 | Akhmat GroznyvZenitPremier League · Russia | 0–2 | Premier League · Russia |
| 2022-04-08 | Atl. TucumanvGimnasia L.P.Copa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-08 | Arsenal SarandivGodoy CruzCopa De La Liga Profesional · Argentina | 3–3 | Copa De La Liga Profesional · Argentina |
| 2022-04-08 | StuttgartvDortmundBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-04-08 | DroghedavBohemiansPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2022-04-08 | PachucavTigres UANLLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-04-08 | ZaglebievStal MielecEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2022-04-08 | Din. BucurestivU Craiova 1948Superliga · Romania | 1–2 | Superliga · Romania |
| 2022-04-08 | LugovCartagenaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-04-08 | Academica ClincenivChindia TargovisteSuperliga · Romania | 0–3 | Superliga · Romania |
| 2022-04-08 | Gil VicentevMoreirensePrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2022-04-08 | NewcastlevWolvesPremier League · England | 1–0 | Premier League · England |
| 2022-04-08 | Queen of SthvPartickChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-04-08 | LorientvSt EtienneLigue 1 · France | 6–2 | Ligue 1 · France |
| 2022-04-08 | St. PatricksvDundalkPremier Division · Ireland | 0–0 | Premier Division · Ireland |
| 2022-04-08 | Go Ahead EaglesvWillem IIEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2022-04-08 | Pogon SzczecinvWisla PlockEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |