| 2021-04-21 | AberdeenvCelticPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-04-21 | Werder BremenvMainzBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-04-21 | HoffenheimvM'gladbachBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-04-21 | JagielloniavStal MielecEkstraklasa · Poland | 3–3 | Ekstraklasa · Poland |
| 2021-04-21 | Piast GliwicevLegiaEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-04-21 | StuttgartvWolfsburgBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2021-04-21 | JuventusvParmaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-04-21 | DortmundvUnion BerlinBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-04-21 | Erzurum BBvYeni MalatyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-04-21 | BetisvAth BilbaoLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-04-21 | HamiltonvMotherwellPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-04-21 | BirminghamvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2021-04-21 | Fortuna DusseldorfvSt Pauli2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-04-21 | LASKvSK RapidBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-04-21 | LyngbyvSonderjyskeSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-04-21 | AnkaragucuvDenizlisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-21 | ElchevValladolidLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-04-21 | RotherhamvMiddlesbroughChampionship · England | 1–2 | Championship · England |
| 2021-04-21 | CracoviavWisla PlockEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-04-21 | AlavesvVillarrealLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-04-21 | MillwallvBournemouthChampionship · England | 1–4 | Championship · England |
| 2021-04-21 | Sepsi Sf. GheorghevCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-04-21 | FC ArgesvChindia TargovisteSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-04-21 | Aston VillavMan CityPremier League · England | 1–2 | Premier League · England |
| 2021-04-21 | LuganovSt. GallenSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-04-21 | TirolvSalzburgBundesliga · Austria | 3–2 | Bundesliga · Austria |
| 2021-04-21 | Sp LisbonvBelenensesPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-04-21 | AalborgvOdenseSuperliga · Denmark | 3–2 | Superliga · Denmark |
| 2021-04-21 | BolognavTorinoSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-04-21 | LutonvReadingChampionship · England | 0–0 | Championship · England |
| 2021-04-21 | CadizvReal MadridLa Liga · Spain | 0–3 | La Liga · Spain |
| 2021-04-21 | LevantevSevillaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-04-21 | FC BotosanivUniv. CraiovaSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-04-21 | HuddersfieldvBarnsleyChampionship · England | 0–1 | Championship · England |
| 2021-04-21 | MilanvSassuoloSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-04-21 | HannovervRegensburg2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-04-21 | SpeziavInterSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-04-21 | Henan Songshan LongmenvShenzhenSuper League · China | 1–2 | Super League · China |
| 2021-04-21 | Sturm GrazvWolfsberger ACBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-04-21 | VaduzvBaselSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-04-21 | PaderbornvOsnabruck2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-04-21 | Qingdao FCvCangzhouSuper League · China | 2–1 | Super League · China |
| 2021-04-21 | LuzernvLausanneSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2021-04-21 | MaritimovRio AvePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-04-21 | ArisvPAOKSuper League · Greece | 0–1 | Super League · Greece |
| 2021-04-21 | OlympiakosvAsteras TripolisSuper League · Greece | 1–0 | Super League · Greece |
| 2021-04-20 | HartbergvSt. PoltenBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-04-20 | SwanseavQPRChampionship · England | 0–1 | Championship · England |
| 2021-04-20 | Pacos FerreiravFarensePrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-04-20 | DumbartonvPartickLeague One · Scotland | 0–2 | League One · Scotland |