| 2010-11-20 | Bristol CityvLeicesterChampionship · England | 2–0 | Championship · England |
| 2010-11-20 | GentvWesterloPro League · Belgium | 4–4 | Pro League · Belgium |
| 2010-11-20 | HullvIpswichChampionship · England | 1–0 | Championship · England |
| 2010-11-20 | CartagenavBetisLaLiga 2 · Spain | 2–1 | LaLiga 2 · Spain |
| 2010-11-20 | GerminalvAnderlechtPro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-11-20 | ManisasporvBursasporSüper Lig · Türkiye | 0–2 | Süper Lig · Türkiye |
| 2010-11-20 | VillarrealvValenciaLaLiga · Spain | 1–1 | LaLiga · Spain |
| 2010-11-20 | AscolivVareseSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-11-20 | CoventryvBurnleyChampionship · England | 1–0 | Championship · England |
| 2010-11-20 | NurnbergvKaiserslauternBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2010-11-20 | SassuolovTriestinaSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-11-20 | St EtiennevAuxerreLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-11-20 | West BromvStokePremier League · England | 0–3 | Premier League · England |
| 2010-11-20 | BoltonvNewcastlePremier League · England | 5–1 | Premier League · England |
| 2010-11-20 | RochdalevSwindonLeague One · England | 3–3 | League One · England |
| 2010-11-20 | AldershotvChesterfieldLeague Two · England | 0–2 | League Two · England |
| 2010-11-20 | PanathinaikosvIraklisSuper League Greece · Greece | 4–2 | Super League Greece · Greece |
| 2010-11-20 | XanthivPanserraikosSuper League Greece · Greece | 2–0 | Super League Greece · Greece |
| 2010-11-20 | CheltenhamvMorecambeLeague Two · England | 1–1 | League Two · England |
| 2010-11-20 | MilanvFiorentinaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-11-20 | Leyton OrientvBournemouthLeague One · England | 2–2 | League One · England |
| 2010-11-20 | ExcelsiorvVVV VenloEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2010-11-20 | GatesheadvForest GreenNational League · England | 1–1 | National League · England |
| 2010-11-20 | AberdeenvSt JohnstonePremiership · Scotland | 0–1 | Premiership · Scotland |
| 2010-11-20 | KasimpasavGenclerbirligiSüper Lig · Türkiye | 1–1 | Süper Lig · Türkiye |
| 2010-11-20 | BirminghamvChelseaPremier League · England | 1–0 | Premier League · England |
| 2010-11-20 | BrightonvBristol RvsLeague One · England | 2–2 | League One · England |
| 2010-11-20 | MiddlesbroughvMillwallChampionship · England | 0–1 | Championship · England |
| 2010-11-20 | Newport CountyvSouthportNational League · England | 2–0 | National League · England |
| 2010-11-20 | DoncastervSwanseaChampionship · England | 1–1 | Championship · England |
| 2010-11-20 | Notts CountyvTranmereLeague One · England | 0–1 | League One · England |
| 2010-11-20 | LeverkusenvBayern MunichBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-11-20 | WrexhamvDarlingtonNational League · England | 2–1 | National League · England |
| 2010-11-20 | FreiburgvDortmundBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-11-20 | Ein FrankfurtvHoffenheimBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2010-11-20 | BarnetvNorthamptonLeague Two · England | 4–1 | League Two · England |
| 2010-11-20 | CambridgevTamworthNational League · England | 3–3 | National League · England |
| 2010-11-20 | NancyvValenciennesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-11-20 | Port ValevWycombeLeague Two · England | 2–1 | League Two · England |
| 2010-11-20 | GrimsbyvBarrowNational League · England | 1–1 | National League · England |
| 2010-11-20 | LincolnvHerefordLeague Two · England | 3–1 | League Two · England |
| 2010-11-20 | St MirrenvMotherwellPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-11-20 | BochumvIngolstadt2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |
| 2010-11-20 | PortogruarovSienaSerie B · Italy | 1–4 | Serie B · Italy |
| 2010-11-20 | CharleroivGenkPro League · Belgium | 1–3 | Pro League · Belgium |
| 2010-11-20 | AjaxvPSV EindhovenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2010-11-20 | DerbyvScunthorpeChampionship · England | 3–2 | Championship · England |
| 2010-11-20 | TorinovModenaSerie B · Italy | 3–2 | Serie B · Italy |
| 2010-11-20 | M'gladbachvMainzBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2010-11-20 | WalsallvCarlisleLeague One · England | 2–1 | League One · England |