| 2010-11-20 | WrexhamvDarlingtonNational League · England | 2–1 | National League · England |
| 2010-11-20 | FreiburgvDortmundBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-11-20 | Ein FrankfurtvHoffenheimBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2010-11-20 | BarnetvNorthamptonLeague Two · England | 4–1 | League Two · England |
| 2010-11-20 | CambridgevTamworthNational League · England | 3–3 | National League · England |
| 2010-11-20 | NancyvValenciennesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-11-20 | Port ValevWycombeLeague Two · England | 2–1 | League Two · England |
| 2010-11-20 | GrimsbyvBarrowNational League · England | 1–1 | National League · England |
| 2010-11-20 | LincolnvHerefordLeague Two · England | 3–1 | League Two · England |
| 2010-11-20 | St MirrenvMotherwellPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-11-20 | BochumvIngolstadt2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |
| 2010-11-20 | PortogruarovSienaSerie B · Italy | 1–4 | Serie B · Italy |
| 2010-11-20 | CharleroivGenkPro League · Belgium | 1–3 | Pro League · Belgium |
| 2010-11-20 | AjaxvPSV EindhovenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2010-11-20 | DerbyvScunthorpeChampionship · England | 3–2 | Championship · England |
| 2010-11-20 | TorinovModenaSerie B · Italy | 3–2 | Serie B · Italy |
| 2010-11-20 | M'gladbachvMainzBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2010-11-20 | WalsallvCarlisleLeague One · England | 2–1 | League One · England |
| 2010-11-20 | LiersevSt TruidenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2010-11-20 | KilmarnockvRangersPremiership · Scotland | 2–3 | Premiership · Scotland |
| 2010-11-20 | HuddersfieldvExeterLeague One · England | 0–1 | League One · England |
| 2010-11-20 | CittadellavPiacenzaSerie B · Italy | 3–0 | Serie B · Italy |
| 2010-11-20 | Milton Keynes DonsvSheffield WedsLeague One · England | 1–4 | League One · England |
| 2010-11-20 | LokerenvMechelenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2010-11-20 | VitessevHeraclesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-11-20 | LiverpoolvWest HamPremier League · England | 3–0 | Premier League · England |
| 2010-11-20 | AlmeriavBarcelonaLa Liga · Spain | 0–8 | La Liga · Spain |
| 2010-11-20 | WatfordvReadingChampionship · England | 1–1 | Championship · England |
| 2010-11-20 | StockportvTorquayLeague Two · England | 1–1 | League Two · England |
| 2010-11-20 | BradfordvMacclesfieldLeague Two · England | 0–1 | League Two · England |
| 2010-11-20 | ToulousevMarseilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-11-20 | LutonvHistonNational League · England | 5–1 | National League · England |
| 2010-11-20 | PlymouthvBrentfordLeague One · England | 1–2 | League One · England |
| 2010-11-20 | ArsenalvTottenhamPremier League · England | 2–3 | Premier League · England |
| 2010-11-20 | SouthamptonvPeterboroLeague One · England | 4–1 | League One · England |
| 2010-11-20 | LivornovEmpoliSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-11-20 | Man UnitedvWiganPremier League · England | 2–0 | Premier League · England |
| 2010-11-20 | NorwichvLeedsChampionship · England | 1–1 | Championship · England |
| 2010-11-20 | CharltonvYeovilLeague One · England | 3–2 | League One · England |
| 2010-11-20 | Schalke 04vWerder BremenBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2010-11-20 | GrossetovAlbinoleffeSerie B · Italy | 3–3 | Serie B · Italy |
| 2010-11-20 | PaderbornvGreuther Furth2. Bundesliga · Germany | 0–4 | 2. Bundesliga · Germany |
| 2010-11-20 | QPRvPrestonChampionship · England | 3–1 | Championship · England |
| 2010-11-20 | OxfordvGillinghamLeague Two · England | 0–1 | League Two · England |
| 2010-11-20 | Sheffield UnitedvCrystal PalaceChampionship · England | 3–2 | Championship · England |
| 2010-11-20 | ShrewsburyvSouthendLeague Two · England | 1–1 | League Two · England |
| 2010-11-20 | AccringtonvStevenageLeague Two · England | 1–0 | League Two · England |
| 2010-11-20 | ColchestervHartlepoolLeague One · England | 3–2 | League One · England |
| 2010-11-20 | KidderminstervEastbourne BoroughNational League · England | 2–1 | National League · England |
| 2010-11-20 | VallecanovPonferradinaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |