| 2000-11-25 | WrexhamvBristol RvsLeague One · England | 1–0 | League One · England |
| 2000-11-25 | CowdenbeathvPeterheadLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2000-11-25 | Ein FrankfurtvHerthaBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2000-11-25 | LouvieroisevLiersePro League · Belgium | 0–2 | Pro League · Belgium |
| 2000-11-25 | TorquayvBarnetLeague Two · England | 2–1 | League Two · England |
| 2000-11-25 | FreiburgvBayern MunichBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2000-11-25 | MilanvNapoliSerie A · Italy | 1–0 | Serie A · Italy |
| 2000-11-25 | PartickvQueen of SthLeague One · Scotland | 2–1 | League One · Scotland |
| 2000-11-25 | FalkirkvAirdrieChampionship · Scotland | 0–2 | Championship · Scotland |
| 2000-11-25 | OldhamvMillwallLeague One · England | 0–1 | League One · England |
| 2000-11-25 | KilmarnockvSt JohnstonePremiership · Scotland | 0–2 | Premiership · Scotland |
| 2000-11-25 | HalifaxvChesterfieldLeague Two · England | 2–2 | League Two · England |
| 2000-11-25 | SouthendvCheltenhamLeague Two · England | 0–1 | League Two · England |
| 2000-11-25 | TroyesvGuingampLigue 1 · France | 0–1 | Ligue 1 · France |
| 2000-11-25 | ScunthorpevMansfieldLeague Two · England | 6–0 | League Two · England |
| 2000-11-25 | CardiffvHartlepoolLeague Two · England | 3–2 | League Two · England |
| 2000-11-25 | OxfordvNotts CountyLeague One · England | 2–3 | League One · England |
| 2000-11-25 | PanathinaikosvXanthiSuper League · Greece | 3–0 | Super League · Greece |
| 2000-11-25 | HullvCarlisleLeague Two · England | 2–1 | League Two · England |
| 2000-11-25 | MouscronvHarelbekePro League · Belgium | 4–3 | Pro League · Belgium |
| 2000-11-25 | BlackpoolvDarlingtonLeague Two · England | 2–1 | League Two · England |
| 2000-11-25 | StranraervStenhousemuirLeague One · Scotland | 1–4 | League One · Scotland |
| 2000-11-25 | CoventryvAston VillaPremier League · England | 1–1 | Premier League · England |
| 2000-11-25 | Queens ParkvClydebankLeague One · Scotland | 1–1 | League One · Scotland |
| 2000-11-25 | ErzurumsporvAdanasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2000-11-25 | CrewevSheffield WedsChampionship · England | 1–0 | Championship · England |
| 2000-11-25 |  Eritreav RwandaCECAFA Cup | 1–1 | CECAFA Cup |
| 2000-11-25 | SamsunsporvAntalyasporSüper Lig · Turkey | 4–2 | Süper Lig · Turkey |
| 2000-11-25 | CambridgevSwanseaLeague One · England | 3–3 | League One · England |
| 2000-11-25 | GerminalvAnderlechtPro League · Belgium | 0–1 | Pro League · Belgium |
| 2000-11-25 | DortmundvWolfsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2000-11-25 | WalsallvNorthamptonLeague One · England | 3–0 | League One · England |
| 2000-11-25 | Bristol CityvWiganLeague One · England | 1–1 | League One · England |
| 2000-11-25 | Sheffield UnitedvBoltonChampionship · England | 1–0 | Championship · England |
| 2000-11-25 | NorwichvWimbledonChampionship · England | 1–2 | Championship · England |
| 2000-11-25 | KidderminstervYorkLeague Two · England | 3–1 | League Two · England |
| 2000-11-25 | AZ AlkmaarvSpartaEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2000-11-25 | MallorcavVillarrealLa Liga · Spain | 2–1 | La Liga · Spain |
| 2000-11-25 | LincolnvExeterLeague Two · England | 3–1 | League Two · England |
| 2000-11-25 | BastiavMarseilleLigue 1 · France | 3–0 | Ligue 1 · France |
| 2000-11-25 | ExtremaduravU.Las PalmasLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2000-11-25 | BirminghamvHuddersfieldChampionship · England | 2–1 | Championship · England |
| 2000-11-25 | BielefeldvM'gladbach2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2000-11-25 | Albion RvsvMontroseLeague Two · Scotland | 3–2 | League Two · Scotland |
| 2000-11-25 | RotherhamvPeterboroLeague One · England | 3–0 | League One · England |
| 2000-11-25 | LleidavBetisLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2000-11-25 | FulhamvGrimsbyChampionship · England | 2–1 | Championship · England |
| 2000-11-25 | GraafschapvFor SittardEredivisie · Netherlands | 5–1 | Eredivisie · Netherlands |
| 2000-11-25 | BrechinvHamiltonLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2000-11-25 | St MirrenvHibernianPremiership · Scotland | 1–1 | Premiership · Scotland |