| 2022-04-09 | BarnetvSolihullNational League · England | 0–2 | National League · England |
| 2022-04-09 | Young BoysvLausanneSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2022-04-09 | GaziantepvTrabzonsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-04-09 | Volos NFCvLamiaSuper League · Greece | 3–0 | Super League · Greece |
| 2022-04-09 | RotherhamvCharltonLeague One · England | 0–1 | League One · England |
| 2022-04-09 | WolfsburgvBielefeldBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-04-09 | Atletico GOvFlamengo RJSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2022-04-09 | AlcorconvSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-04-09 | BoltonvSheffield WedsLeague One · England | 1–1 | League One · England |
| 2022-04-09 | HalifaxvWokingNational League · England | 2–1 | National League · England |
| 2022-04-09 | OFI CretevApollonSuper League · Greece | 1–2 | Super League · Greece |
| 2022-04-09 | Piast GliwicevLecznaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-04-09 | HerthavUnion BerlinBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-04-09 | LillestromvJervEliteserien · Norway | 4–0 | Eliteserien · Norway |
| 2022-04-09 | EmpolivSpeziaSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-04-09 | SundsvallvHammarbyAllsvenskan · Sweden | 1–5 | Allsvenskan · Sweden |
| 2022-04-09 | IlvesvKuPSVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |
| 2022-04-09 | LivingstonvMotherwellPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2022-04-09 | Raith RvsvMortonChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-04-09 | Inter MiamivNew England RevolutionMLS · United States | 3–2 | MLS · United States |
| 2022-04-09 | CheltenhamvPortsmouthLeague One · England | 1–0 | League One · England |
| 2022-04-09 | ReadingvCardiffChampionship · England | 1–2 | Championship · England |
| 2022-04-09 | Talleres CordobavDefensa y JusticiaCopa De La Liga Profesional · Argentina | 1–5 | Copa De La Liga Profesional · Argentina |
| 2022-04-09 | Sociedad BvTenerifeLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-04-09 | Pacos FerreiravMaritimoPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-04-09 | EvertonvMan UnitedPremier League · England | 1–0 | Premier League · England |
| 2022-04-09 | AjaxvSparta RotterdamEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-04-09 | BlackburnvBlackpoolChampionship · England | 1–1 | Championship · England |
| 2022-04-09 | Bristol CityvPeterboroChampionship · England | 1–1 | Championship · England |
| 2022-04-09 | Dundee UnitedvDundeePremiership · Scotland | 2–2 | Premiership · Scotland |
| 2022-04-09 | TirolvAltachBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2022-04-09 | Rosario CentralvColon Santa FECopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-09 | PrestonvQPRChampionship · England | 2–1 | Championship · England |
| 2022-04-09 | Kelty HeartsvStirlingLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2022-04-09 | MalagavValladolidLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2022-04-09 | AdmiravLASKBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2022-04-09 | IndependientevTigreCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-09 | Erzgebirge AuevHannover2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2022-04-09 | CambridgevMorecambeLeague One · England | 2–1 | League One · England |
| 2022-04-09 | AuxerrevValenciennesLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-04-09 | SouthamptonvChelseaPremier League · England | 0–6 | Premier League · England |
| 2022-04-09 | TondelavSp LisbonPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2022-04-09 | CelticvSt JohnstonePremiership · Scotland | 7–0 | Premiership · Scotland |
| 2022-04-09 | GrasshoppersvLuzernSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2022-04-09 | WatfordvLeedsPremier League · England | 0–3 | Premier League · England |
| 2022-04-09 | GoztepvKayserisporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-04-09 | SwanseavDerbyChampionship · England | 2–1 | Championship · England |
| 2022-04-09 | SuttonvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2022-04-09 | SochauxvNancyLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-04-09 | VillarrealvAth BilbaoLa Liga · Spain | 1–1 | La Liga · Spain |