| 2021-04-23 | Willem IIvWaalwijkEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-04-23 | UTA AradvFC HermannstadtSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-04-23 | Shamrock RoversvBohemiansPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-04-23 | RakowvSlask WroclawEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-04-23 | GenclerbirligivRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-04-22 | AlanyasporvGaziantepSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2021-04-22 | Dalian ProvChangchun YataiSuper League · China | 1–2 | Super League · China |
| 2021-04-22 | TondelavNacionalPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-04-22 | Ath MadridvHuescaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-04-22 | PortimonensevBenficaPrimeira Liga · Portugal | 1–5 | Primeira Liga · Portugal |
| 2021-04-22 | ZurichvYoung BoysSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-04-22 | GranadavEibarLa Liga · Spain | 4–1 | La Liga · Spain |
| 2021-04-22 | Poli IasivFC VoluntariSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-04-22 | MidtjyllandvFC CopenhagenSuperliga · Denmark | 4–1 | Superliga · Denmark |
| 2021-04-22 | MonterreyvGuadalajara ChivasLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-04-22 | RomavAtalantaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-04-22 | KasimpasavBuyuksehyrSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-04-22 | PortovGuimaraesPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-04-22 | Academica ClincenivFCSBSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-04-22 | SociedadvCeltaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-04-22 | Gil VicentevFamalicaoPrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-04-22 | BarcelonavGetafeLa Liga · Spain | 5–2 | La Liga · Spain |
| 2021-04-22 | VejlevHorsensSuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2021-04-22 | Nagoya GrampusvGamba OsakaJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-04-22 | AarhusvRanders FCSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-04-22 | LeicestervWest BromPremier League · England | 3–0 | Premier League · England |
| 2021-04-22 | SandhausenvHamburg2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-04-22 | ServettevSionSuper League · Switzerland | 3–5 | Super League · Switzerland |
| 2021-04-22 | AjaxvUtrechtEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-04-22 | NapolivLazioSerie A · Italy | 5–2 | Serie A · Italy |
| 2021-04-22 | Tianjin Jinmen TigervShanghai PortSuper League · China | 1–6 | Super League · China |
| 2021-04-21 | ZaglebievWislaEkstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2021-04-21 | HibernianvLivingstonPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-04-21 | StokevCoventryChampionship · England | 2–3 | Championship · England |
| 2021-04-21 | CrotonevSampdoriaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-04-21 | HeidenheimvBochum2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2021-04-21 | Ross CountyvSt MirrenPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2021-04-21 | GalatasarayvTrabzonsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-21 | MirandesvTenerifeLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-04-21 | Santa ClaravMoreirensePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-04-21 | OsasunavValenciaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-04-21 | UdinesevCagliariSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-04-21 | Sp BragavBoavistaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-04-21 | NordsjaellandvBrondbySuperliga · Denmark | 0–3 | Superliga · Denmark |
| 2021-04-21 | KilmarnockvDundee UnitedPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2021-04-21 | TottenhamvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2021-04-21 | St JohnstonevRangersPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-04-21 | AEKvPanathinaikosSuper League · Greece | 1–1 | Super League · Greece |
| 2021-04-21 | GenoavBeneventoSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-04-21 | WycombevBristol CityChampionship · England | 2–1 | Championship · England |