| 2022-04-09 | Orlando CityvChicago FireMLS · United States | 1–0 | MLS · United States |
| 2022-04-09 | WeymouthvGrimsbyNational League · England | 0–0 | National League · England |
| 2022-04-09 | LeccevSpalSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-09 | Aston VillavTottenhamPremier League · England | 0–4 | Premier League · England |
| 2022-04-09 | NijmegenvTwenteEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2022-04-09 | Lech PoznanvLegiaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-04-09 | ElginvStenhousemuirLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2022-04-09 | BromleyvDag and RedNational League · England | 0–2 | National League · England |
| 2022-04-09 | BenficavBelenensesPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2022-04-09 | AlloavClydeLeague One · Scotland | 1–0 | League One · Scotland |
| 2022-04-09 | MontrosevAirdrie UtdLeague One · Scotland | 2–2 | League One · Scotland |
| 2022-04-09 | Port ValevOldhamLeague Two · England | 3–2 | League Two · England |
| 2022-04-09 | Kings LynnvYeovilNational League · England | 2–2 | National League · England |
| 2022-04-09 | Union de Santa FevNewells Old BoysCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-09 | MillwallvBarnsleyChampionship · England | 4–1 | Championship · England |
| 2022-04-09 | DumbartonvPeterheadLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-04-09 | NurnbergvDarmstadt2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2022-04-09 | EupenvOostendePro League · Belgium | 0–2 | Pro League · Belgium |
| 2022-04-09 | NiortvNimesLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-04-09 | KhimkivCSKA MoscowPremier League · Russia | 4–2 | Premier League · Russia |
| 2022-04-09 | AmiensvBastiaLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-04-09 | GuingampvToulouseLigue 2 · France | 2–4 | Ligue 2 · France |
| 2022-04-09 | Dover AthleticvMaidenheadNational League · England | 0–1 | National League · England |
| 2022-04-09 | Greuther FurthvM'gladbachBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-04-09 | WrexhamvEastleighNational League · England | 3–2 | National League · England |
| 2022-04-09 | Philadelphia UnionvColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2022-04-09 | WealdstonevChesterfieldNational League · England | 1–2 | National League · England |
| 2022-04-09 | AberdeenvRoss CountyPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2022-04-09 | HeartsvHibernianPremiership · Scotland | 3–1 | Premiership · Scotland |
| 2022-04-09 | ComovCittadellaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-04-09 | IntervVeronaSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-04-09 | St PaulivWerder Bremen2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-09 | Pari NNvDynamo MoscowPremier League · Russia | 0–1 | Premier League · Russia |
| 2022-04-09 | ShrewsburyvIpswichLeague One · England | 1–1 | League One · England |
| 2022-04-09 | Sarmiento JuninvSan LorenzoCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-09 | Bayern MunichvAugsburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-04-09 | StockportvSouthendNational League · England | 5–0 | National League · England |
| 2022-04-09 | New York Red BullsvCF MontrealMLS · United States | 1–2 | MLS · United States |
| 2022-04-09 | Lechia GdanskvTermalica B-B.Ekstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2022-04-09 | RochdalevWalsallLeague Two · England | 1–0 | League Two · England |
| 2022-04-09 | CarlislevExeterLeague Two · England | 0–1 | League Two · England |
| 2022-04-09 | AFC WimbledonvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2022-04-09 | Albion RvsvStranraerLeague Two · Scotland | 0–5 | League Two · Scotland |
| 2022-04-09 | RizesporvKonyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-04-09 | FC ArgesvFarul ConstantaSuperliga · Romania | 0–2 | Superliga · Romania |
| 2022-04-09 | KilmarnockvDunfermlineChampionship · Scotland | 2–0 | Championship · Scotland |
| 2022-04-09 | Sheffield UnitedvBournemouthChampionship · England | 0–0 | Championship · England |
| 2022-04-09 | Atl. San LuisvClub LeonLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-04-09 | West BromvStokeChampionship · England | 1–3 | Championship · England |
| 2022-04-09 | ReimsvRennesLigue 1 · France | 2–3 | Ligue 1 · France |