| 2021-04-24 | MaidenheadvWokingNational League · England | 2–1 | National League · England |
| 2021-04-24 | ExetervNewport CountyLeague Two · England | 0–0 | League Two · England |
| 2021-04-24 | ParmavCrotoneSerie A · Italy | 3–4 | Serie A · Italy |
| 2021-04-24 | TambovvLokomotiv MoscowPremier League · Russia | 2–5 | Premier League · Russia |
| 2021-04-24 | PonferradinavLugoLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-04-24 | AdmiravAustria ViennaBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2021-04-24 | StenhousemuirvCowdenbeathLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2021-04-24 | LarisavOFI CreteSuper League · Greece | 0–1 | Super League · Greece |
| 2021-04-24 | Milton Keynes DonsvSwindonLeague One · England | 5–0 | League One · England |
| 2021-04-24 | SolihullvYeovilNational League · England | 5–1 | National League · England |
| 2021-04-24 | PSV EindhovenvGroningenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-04-24 | FC TokyovSagan TosuJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-04-24 | PordenonevPisaSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-04-24 | Cruz AzulvAtl. San LuisLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2021-04-24 | BlackpoolvShrewsburyLeague One · England | 0–1 | League One · England |
| 2021-04-24 | Mazatlan FCvClub LeonLiga MX · Mexico | 4–3 | Liga MX · Mexico |
| 2021-04-24 | Toronto FCvVancouver WhitecapsMLS · United States | 2–2 | MLS · United States |
| 2021-04-24 | DerbyvBirminghamChampionship · England | 1–2 | Championship · England |
| 2021-04-24 | TorquayvNotts CountyNational League · England | 2–2 | National League · England |
| 2021-04-24 | AtromitosvLamiaSuper League · Greece | 0–0 | Super League · Greece |
| 2021-04-24 | DundalkvDroghedaPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-04-24 | HeartsvInverness CChampionship · Scotland | 3–0 | Championship · Scotland |
| 2021-04-24 | MorecambevBoltonLeague Two · England | 0–1 | League Two · England |
| 2021-04-24 | Gornik Z.vWisla PlockEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-04-24 | CharltonvPeterboroLeague One · England | 0–1 | League One · England |
| 2021-04-24 | DunfermlinevArbroathChampionship · Scotland | 4–3 | Championship · Scotland |
| 2021-04-24 | UralvAkhmat GroznyPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-04-24 | Nott'm ForestvStokeChampionship · England | 1–1 | Championship · England |
| 2021-04-24 | ZaglebievPiast GliwiceEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-04-24 | IpswichvAFC WimbledonLeague One · England | 0–0 | League One · England |
| 2021-04-24 | GillinghamvNorthamptonLeague One · England | 2–2 | League One · England |
| 2021-04-24 | AltachvHartbergBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-04-24 | LogronesvCartagenaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-04-24 | St EtiennevBrestLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-04-24 | HeerenveenvZwolleEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-04-24 | PartickvAirdrie UtdLeague One · Scotland | 1–0 | League One · Scotland |
| 2021-04-24 | SouthendvLeyton OrientLeague Two · England | 2–1 | League Two · England |
| 2021-04-24 | DenizlisporvSivassporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-23 | Queens ParkvStranraerLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-04-23 | ReimsvMarseilleLigue 1 · France | 1–3 | Ligue 1 · France |
| 2021-04-23 | ZaragozavSp GijonLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-04-23 | KarlsruhevWurzburger Kickers2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-04-23 | HebeivWuhan FCSuper League · China | 1–1 | Super League · China |
| 2021-04-23 | BraunschweigvErzgebirge Aue2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2021-04-23 | Gaz Metan MediasvDin. BucurestiSuperliga · Romania | 4–1 | Superliga · Romania |
| 2021-04-23 | PodbeskidzievLech PoznanEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-04-23 | Shanghai ShenhuavBeijing GuoanSuper League · China | 2–1 | Super League · China |
| 2021-04-23 | ArsenalvEvertonPremier League · England | 0–1 | Premier League · England |
| 2021-04-23 | AugsburgvFC KolnBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-04-23 | Finn HarpsvSt. PatricksPremier Division · Ireland | 0–2 | Premier Division · Ireland |