| 2022-04-10 | LensvNiceLigue 1 · France | 3–0 | Ligue 1 · France |
| 2022-04-10 | OsasunavAlavesLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-04-10 | MarseillevMontpellierLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-04-10 | Houston DynamovSan Jose EarthquakesMLS · United States | 4–3 | MLS · United States |
| 2022-04-10 | PerugiavPisaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-04-10 | Club AmericavJuarezLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2022-04-10 | Atletico-MGvInternacionalSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2022-04-10 | SK RapidvWolfsberger ACBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2022-04-10 | SandhausenvDresden2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-04-10 | Yeni MalatyasporvGiresunsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2022-04-10 | FenerbahcevGalatasaraySüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2022-04-10 | KyotovSagan TosuJ1 League · Japan | 3–1 | J1 League · Japan |
| 2022-04-10 | OviedovLeganesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-04-10 | CrotonevTernanaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-04-10 | ZwollevAZ AlkmaarEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-04-10 | Ein FrankfurtvFreiburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-04-10 | St TruidenvStandardPro League · Belgium | 3–0 | Pro League · Belgium |
| 2022-04-10 | TorinovMilanSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-04-10 | CosenzavMonzaSerie B · Italy | 0–2 | Serie B · Italy |
| 2022-04-10 | FC DallasvColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2022-04-10 | Los Angeles GalaxyvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2022-04-10 | Spartak MoscowvArsenal TulaPremier League · Russia | 3–0 | Premier League · Russia |
| 2022-04-10 | RB LeipzigvHoffenheimBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-04-10 | Club BruggevMechelenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-04-10 | VitessevCambuurEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-04-09 | Kawasaki FrontalevKashiwa ReysolJ1 League · Japan | 1–0 | J1 League · Japan |
| 2022-04-09 | HIFKvMariehamnVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2022-04-09 | RiedvHartbergBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2022-04-09 | AjacciovPau FCLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-09 | Nott'm ForestvBirminghamChampionship · England | 2–0 | Championship · England |
| 2022-04-09 | FC KolnvMainzBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-04-09 | MallorcavAth MadridLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-04-09 | Forest GreenvHartlepoolLeague Two · England | 1–1 | League Two · England |
| 2022-04-09 | Rubin KazanvKrasnodarPremier League · Russia | 0–1 | Premier League · Russia |
| 2022-04-09 | Asteras TripolisvIonikosSuper League · Greece | 2–3 | Super League · Greece |
| 2022-04-09 | Mazatlan FCvCruz AzulLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-04-09 | UtrechtvFor SittardEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-04-09 | LincolnvWiganLeague One · England | 1–3 | League One · England |
| 2022-04-09 | TranmerevBristol RvsLeague Two · England | 1–1 | League Two · England |
| 2022-04-09 | GrenoblevCaenLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-04-09 | BoavistavAroucaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-04-09 | CadizvBetisLa Liga · Spain | 1–2 | La Liga · Spain |
| 2022-04-09 | BesiktasvAlanyasporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2022-04-09 | TorquayvNotts CountyNational League · England | 5–1 | National League · England |
| 2022-04-09 | PanetolikosvAtromitosSuper League · Greece | 2–3 | Super League · Greece |
| 2022-04-09 | Schalke 04vHeidenheim2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-04-09 | Queens ParkvEast FifeLeague One · Scotland | 1–0 | League One · Scotland |
| 2022-04-09 | AlessandriavPordenoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-04-09 | FluminensevSantosSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2022-04-09 | PueblavUNAM PumasLiga MX · Mexico | 2–2 | Liga MX · Mexico |