| 2021-04-24 | LeverkusenvEin FrankfurtBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-04-24 | PaderbornvFortuna Dusseldorf2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-04-24 | SassuolovSampdoriaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-04-24 | HackenvSiriusAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-04-24 | AstravFC ArgesSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-04-24 | WislavCracoviaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-04-24 | CarlislevHarrogateLeague Two · England | 1–1 | League Two · England |
| 2021-04-24 | PortsmouthvBristol RvsLeague One · England | 1–0 | League One · England |
| 2021-04-24 | Inter TurkuvKuPSVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2021-04-24 | Los Angeles FCvSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2021-04-24 | Port ValevBradfordLeague Two · England | 2–1 | League Two · England |
| 2021-04-24 | Sporting Kansas CityvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2021-04-24 | ValenciennesvNiortLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-24 | GenoavSpeziaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-04-24 | WolfsburgvDortmundBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-04-24 | ScunthorpevWalsallLeague Two · England | 0–2 | League Two · England |
| 2021-04-24 | CheltenhamvColchesterLeague Two · England | 1–0 | League Two · England |
| 2021-04-24 | SalfordvMansfieldLeague Two · England | 2–0 | League Two · England |
| 2021-04-24 | RodezvLe HavreLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-24 | SochauxvCaenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-04-24 | LausannevBaselSuper League · Switzerland | 3–3 | Super League · Switzerland |
| 2021-04-24 | FalkirkvCove RangersLeague One · Scotland | 2–2 | League One · Scotland |
| 2021-04-24 | St. GallenvVaduzSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2021-04-24 | Albion RvsvAnnan AthleticLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-04-24 | Hokkaido Consadole SapporovVegalta SendaiJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-04-24 | BournemouthvBrentfordChampionship · England | 0–1 | Championship · England |
| 2021-04-24 | HJKvHonkaVeikkausliiga · Finland | 4–2 | Veikkausliiga · Finland |
| 2021-04-24 | Argentinos JrsvBanfieldCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-24 | WrexhamvChesterfieldNational League · England | 0–0 | National League · England |
| 2021-04-24 | WatfordvMillwallChampionship · England | 1–0 | Championship · England |
| 2021-04-24 | DundeevRaith RvsChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-04-24 | BlackburnvHuddersfieldChampionship · England | 5–2 | Championship · England |
| 2021-04-24 | Real MadridvBetisLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-04-24 | Sligo RoversvDerry CityPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-04-24 | AjacciovAmiensLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-04-24 | DoncastervFleetwood TownLeague One · England | 0–1 | League One · England |
| 2021-04-24 | Club TijuanavNecaxaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-04-24 | TrabzonsporvKaragumrukSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-04-24 | Union BerlinvWerder BremenBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-04-24 | BesiktasvKayserisporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-04-24 | AldershotvWealdstoneNational League · England | 2–0 | National League · England |
| 2021-04-24 | Dynamo MoscowvKhimkiPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-04-24 | HuracanvBoca JuniorsCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2021-04-24 | OldhamvGrimsbyLeague Two · England | 1–2 | League Two · England |
| 2021-04-24 | CrewevRochdaleLeague One · England | 1–1 | League One · England |
| 2021-04-24 | Godoy CruzvCentral CordobaCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-24 | LiverpoolvNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-04-24 | Yokohama F. MarinosvYokohama FCJ1 League · Japan | 5–0 | J1 League · Japan |
| 2021-04-24 | MetzvParis SGLigue 1 · France | 1–3 | Ligue 1 · France |
| 2021-04-24 | Crawley TownvForest GreenLeague Two · England | 0–0 | League Two · England |