| 2022-04-10 | SeraingvGenkPro League · Belgium | 0–2 | Pro League · Belgium |
| 2022-04-10 | GuimaraesvPortoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-04-10 | BordeauxvMetzLigue 1 · France | 3–1 | Ligue 1 · France |
| 2022-04-10 | FC CopenhagenvMidtjyllandSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2022-04-10 | SandefjordvBodo/GlimtEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2022-04-10 | ElchevSociedadLa Liga · Spain | 1–2 | La Liga · Spain |
| 2022-04-10 | VizelavSp BragaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-04-10 | LeicestervCrystal PalacePremier League · England | 2–1 | Premier League · England |
| 2022-04-10 | VarbergvKalmarAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2022-04-10 | St. GilloisevBeerschot VAPro League · Belgium | 5–0 | Pro League · Belgium |
| 2022-04-10 | Nagoya GrampusvHokkaido Consadole SapporoJ1 League · Japan | 0–2 | J1 League · Japan |
| 2022-04-10 | GentvOud-Heverlee LeuvenPro League · Belgium | 5–0 | Pro League · Belgium |
| 2022-04-10 | VeneziavUdineseSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-04-10 | Warta PoznanvCracoviaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-04-10 | CharlottevAtlanta UtdMLS · United States | 1–0 | MLS · United States |
| 2022-04-10 | Sao PaulovAthletico-PRSerie A · Brazil | 4–0 | Serie A · Brazil |
| 2022-04-10 | PaderbornvKarlsruhe2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-10 | AscolivRegginaSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-04-10 | SassuolovAtalantaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-04-10 | St MirrenvRangersPremiership · Scotland | 0–4 | Premiership · Scotland |
| 2022-04-10 | MonterreyvSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-04-10 | FortalezavCuiabaSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-04-10 | Man CityvLiverpoolPremier League · England | 2–2 | Premier League · England |
| 2022-04-10 |  MonacovTroyesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-10 | AvaivAmerica MGSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2022-04-10 | UralvKrylya SovetovPremier League · Russia | 0–1 | Premier League · Russia |
| 2022-04-10 | LuganovSionSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2022-04-10 | StrasbourgvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-04-10 | PortimonensevFamalicaoPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-04-10 | PalmeirasvCearaSerie A · Brazil | 2–3 | Serie A · Brazil |
| 2022-04-10 | WislavGornik Z.Ekstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2022-04-10 | EspanolvCeltaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-04-10 | LevantevBarcelonaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2022-04-10 | PSV EindhovenvWaalwijkEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2022-04-10 | GenoavLazioSerie A · Italy | 1–4 | Serie A · Italy |
| 2022-04-10 | BrentfordvWest HamPremier League · England | 2–0 | Premier League · England |
| 2022-04-10 | SilkeborgvBrondbySuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2022-04-10 | NordsjaellandvAarhusSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2022-04-10 | Kashima AntlersvYokohama F. MarinosJ1 League · Japan | 0–3 | J1 League · Japan |
| 2022-04-10 | UfavSochiPremier League · Russia | 1–2 | Premier League · Russia |
| 2022-04-10 | CoritibavGoiasSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2022-04-10 | IbizavEibarLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2022-04-10 | FK RostovvLokomotiv MoscowPremier League · Russia | 4–1 | Premier League · Russia |
| 2022-04-10 | VikingvAalesundEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2022-04-10 | KristiansundvSarpsborg 08Eliteserien · Norway | 2–3 | Eliteserien · Norway |
| 2022-04-10 | ZaragozavGironaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-04-10 | StromsgodsetvMoldeEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2022-04-10 | FulhamvCoventryChampionship · England | 1–3 | Championship · England |
| 2022-04-10 | Botafogo RJvCorinthiansSerie A · Brazil | 1–3 | Serie A · Brazil |
| 2022-04-10 | Sturm GrazvAustria ViennaBundesliga · Austria | 1–0 | Bundesliga · Austria |