| 2021-04-25 | Wolfsberger ACvSalzburgBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2021-04-25 | LuzernvZurichSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2021-04-25 | RennesvDijonLigue 1 · France | 5–1 | Ligue 1 · France |
| 2021-04-25 | MirandesvAlmeriaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-04-25 | BoavistavMaritimoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-04-25 | AtlasvGuadalajara ChivasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-04-25 | Shimizu S-PulsevShonan BellmareJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-04-25 | WolvesvBurnleyPremier League · England | 0–4 | Premier League · England |
| 2021-04-25 | Asteras TripolisvArisSuper League · Greece | 1–1 | Super League · Greece |
| 2021-04-25 | Bristol CityvLutonChampionship · England | 2–3 | Championship · England |
| 2021-04-25 | Sturm GrazvLASKBundesliga · Austria | 3–1 | Bundesliga · Austria |
| 2021-04-25 | New England RevolutionvDC UnitedMLS · United States | 1–0 | MLS · United States |
| 2021-04-25 | LeedsvMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2021-04-25 | Philadelphia UnionvInter MiamiMLS · United States | 1–2 | MLS · United States |
| 2021-04-25 | FK RostovvArsenal TulaPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-04-25 | IntervVeronaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-04-25 | AlcorconvLeganesLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-04-25 | FeyenoordvVitesseEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-04-25 | RegensburgvHamburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-04-25 | LorientvBordeauxLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-04-25 | LuganovServetteSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2021-04-25 | Aston VillavWest BromPremier League · England | 2–2 | Premier League · England |
| 2021-04-25 | RB LeipzigvStuttgartBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-04-25 | SonderjyskevVejleSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-04-25 | OdensevLyngbySuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-04-25 | Spartak MoscowvCSKA MoscowPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-04-25 | HorsensvAalborgSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-04-25 | KalmarvOrebroAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-04-25 | FenerbahcevKasimpasaSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2021-04-25 | NicevMontpellierLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-04-25 | BuyuksehyrvAlanyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-25 | AtalantavBolognaSerie A · Italy | 5–0 | Serie A · Italy |
| 2021-04-25 | Defensa y JusticiavArsenal SarandiCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-25 | Rubin KazanvKrasnodarPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-04-25 | TenerifevCastellonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-04-25 | FCSBvSepsi Sf. GheorgheSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-04-25 | Racing ClubvColon Santa FECopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-25 | GaziantepvErzurum BBSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-04-25 | SevillavGranadaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-04-25 | StrasbourgvNantesLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-04-25 | Stal MielecvPogon SzczecinEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-04-25 | OviedovGironaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-04-25 | AjaxvAZ AlkmaarEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-04-25 | VarbergvDjurgardenAllsvenskan · Sweden | 1–3 | Allsvenskan · Sweden |
| 2021-04-25 | UfavSochiPremier League · Russia | 2–3 | Premier League · Russia |
| 2021-04-25 | Malmo FFvOstersundsAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-04-25 | BeneventovUdineseSerie A · Italy | 2–4 | Serie A · Italy |
| 2021-04-25 | SK RapidvTirolBundesliga · Austria | 4–0 | Bundesliga · Austria |
| 2021-04-24 | RiedvSt. PoltenBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-04-24 | San Jose EarthquakesvFC DallasMLS · United States | 3–1 | MLS · United States |