| 2022-04-15 | HuddersfieldvQPRChampionship · England | 2–2 | Championship · England |
| 2022-04-15 | Chindia TargovistevFC BotosaniSuperliga · Romania | 1–2 | Superliga · Romania |
| 2022-04-15 | West BromvBlackpoolChampionship · England | 2–1 | Championship · England |
| 2022-04-15 | AroucavSanta ClaraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-04-15 | MaidenheadvWeymouthNational League · England | 2–0 | National League · England |
| 2022-04-15 | AldosivivRosario CentralCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-15 | YeovilvAldershotNational League · England | 0–2 | National League · England |
| 2022-04-15 | DundalkvSligo RoversPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2022-04-15 | ExetervColchesterLeague Two · England | 2–0 | League Two · England |
| 2022-04-15 | Inverness CvKilmarnockChampionship · Scotland | 2–1 | Championship · Scotland |
| 2022-04-15 | SunderlandvShrewsburyLeague One · England | 3–2 | League One · England |
| 2022-04-15 | Shamrock RoversvSt. PatricksPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2022-04-15 | SouthendvWealdstoneNational League · England | 0–1 | National League · England |
| 2022-04-15 | CheltenhamvGillinghamLeague One · England | 2–2 | League One · England |
| 2022-04-15 | HartlepoolvPort ValeLeague Two · England | 0–1 | League Two · England |
| 2022-04-15 | HammarbyvMjallbyAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2022-04-15 | MilanvGenoaSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-04-15 | StokevBristol CityChampionship · England | 0–1 | Championship · England |
| 2022-04-15 | PeterborovBlackburnChampionship · England | 2–1 | Championship · England |
| 2022-04-15 | Newport CountyvCrawley TownLeague Two · England | 1–2 | League Two · England |
| 2022-04-15 | CharltonvMorecambeLeague One · England | 2–3 | League One · England |
| 2022-04-15 | DoncastervBoltonLeague One · England | 1–2 | League One · England |
| 2022-04-15 | SpeziavInterSerie A · Italy | 1–3 | Serie A · Italy |
| 2022-04-15 | BohemiansvFinn HarpsPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2022-04-15 | BournemouthvMiddlesbroughChampionship · England | 0–0 | Championship · England |
| 2022-04-15 | KayserisporvRizesporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-04-14 | AarhusvViborgSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2022-04-14 | SilkeborgvFC CopenhagenSuperliga · Denmark | 3–1 | Superliga · Denmark |
| 2022-04-14 | OdensevVejleSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2022-04-14 | BrondbyvAalborgSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2022-04-14 | CosenzavBeneventoSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-14 | Guadalajara ChivasvMonterreyLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2022-04-13 | Randers FCvMidtjyllandSuperliga · Denmark | 1–3 | Superliga · Denmark |
| 2022-04-12 | PachucavClub TijuanaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2022-04-12 | JuventudevBragantinoSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2022-04-12 | PortsmouthvRotherhamLeague One · England | 3–0 | League One · England |
| 2022-04-12 | LanusvAldosiviCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-12 | BurtonvWiganLeague One · England | 0–0 | League One · England |
| 2022-04-11 | QueretarovTigres UANLLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-11 | Paris FCvDijonLigue 2 · France | 2–2 | Ligue 2 · France |
| 2022-04-11 | Radomiak RadomvJagielloniaEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2022-04-11 | AlmeriavPonferradinaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2022-04-11 | Gaz Metan MediasvMioveniSuperliga · Romania | 1–2 | Superliga · Romania |
| 2022-04-11 | HuracanvBarracas CentralCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-11 | BresciavParmaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-11 | VarnamovSiriusAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2022-04-11 | Austin FCvMinnesota UnitedMLS · United States | 1–0 | MLS · United States |
| 2022-04-11 | Malmo FFvElfsborgAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2022-04-11 | HuddersfieldvLutonChampionship · England | 2–0 | Championship · England |
| 2022-04-11 | BolognavSampdoriaSerie A · Italy | 2–0 | Serie A · Italy |