| 2021-04-26 | LeicestervCrystal PalacePremier League · England | 2–1 | Premier League · England |
| 2021-04-26 | QueretarovJuarezLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-04-26 | ShenzhenvQingdao FCSuper League · China | 0–0 | Super League · China |
| 2021-04-26 | Rosario CentralvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-26 | ApollonvVolos NFCSuper League · Greece | 0–0 | Super League · Greece |
| 2021-04-26 | BenficavSanta ClaraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-04-26 | NacionalvGuimaraesPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-04-26 | GoteborgvDegerforsAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-04-26 | TorinovNapoliSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-04-25 | Tigres UANLvMonterreyLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-04-25 | Sp BragavSp LisbonPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-04-25 | PAOKvPanathinaikosSuper League · Greece | 0–0 | Super League · Greece |
| 2021-04-25 | AIKvHammarbyAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-04-25 | St PaulivGreuther Furth2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-04-25 | FC EmmenvHeraclesEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-04-25 | Ath BilbaovAth MadridLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-04-25 | LensvNimesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-04-25 | HuescavGetafeLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-04-25 | Yeni MalatyasporvAnkaragucuSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-04-25 | M'gladbachvBielefeldBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2021-04-25 | VillarrealvBarcelonaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-04-25 | Warta PoznanvJagielloniaEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-04-25 | CeltavOsasunaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-04-25 | TolucavClub AmericaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-04-25 | Young BoysvSionSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-04-25 | LanusvVelez SarsfieldCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2021-04-25 | Urawa RedsvOita TrinitaJ1 League · Japan | 3–2 | J1 League · Japan |
| 2021-04-25 | OlympiakosvAEKSuper League · Greece | 2–0 | Super League · Greece |
| 2021-04-25 | AarhusvFC CopenhagenSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2021-04-25 | TwentevUtrechtEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-04-25 | FC BotosanivAcademica ClinceniSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-04-25 | FiorentinavJuventusSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-04-25 | CagliarivRomaSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-04-25 | Chindia TargovistevPoli IasiSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-04-25 | Den HaagvFor SittardEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2021-04-25 | NorrkopingvHalmstadAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-04-25 | Colorado RapidsvAustin FCMLS · United States | 1–3 | MLS · United States |
| 2021-04-25 | Union de Santa FevIndependienteCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-25 | Minnesota UnitedvReal Salt LakeMLS · United States | 1–2 | MLS · United States |
| 2021-04-25 | SandhausenvHannover2. Bundesliga · Germany | 4–2 | 2. Bundesliga · Germany |
| 2021-04-25 | ReadingvSwanseaChampionship · England | 2–2 | Championship · England |
| 2021-04-25 | BrondbyvRanders FCSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-04-25 | Los Angeles GalaxyvNew York Red BullsMLS · United States | 3–2 | MLS · United States |
| 2021-04-25 | Portland TimbersvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2021-04-25 | Atlanta UtdvChicago FireMLS · United States | 3–1 | MLS · United States |
| 2021-04-25 | Angersv MonacoLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-04-25 | Lechia GdanskvLegiaEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-04-25 | Rio AvevPacos FerreiraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-04-25 | LyonvLilleLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-04-25 | River PlatevSan LorenzoCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |