| 2019-04-21 | HammarbyvAFC EskilstunaAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2019-04-21 | UralvRubin KazanRussian Premier League · Russia | 2–1 | Russian Premier League · Russia |
| 2019-04-21 | PAOKvLevadeiakosSuper League Greece · Greece | 5–0 | Super League Greece · Greece |
| 2019-04-21 | New England RevolutionvNew York Red BullsMLS · United States | 1–0 | MLS · United States |
| 2019-04-21 | RegensburgvMagdeburg2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2019-04-21 | BielefeldvIngolstadt2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2019-04-21 | Cruz AzulvUNAM PumasLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2019-04-21 | LevantevEspanolLaLiga · Spain | 2–2 | LaLiga · Spain |
| 2019-04-21 | Wuhan FCvShanghai ShenhuaChinese Super League · China | 1–1 | Chinese Super League · China |
| 2019-04-21 | AlanyasporvFenerbahceSüper Lig · Türkiye | 1–0 | Süper Lig · Türkiye |
| 2019-04-21 | Dalian Yifang F.C.vChongqing Liangjiang AthleticChinese Super League · China | 1–1 | Chinese Super League · China |
| 2019-04-21 | ExcelsiorvWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2019-04-21 | Real MadridvAth BilbaoLaLiga · Spain | 3–0 | LaLiga · Spain |
| 2019-04-21 | BuyuksehyrvRizesporSüper Lig · Türkiye | 1–1 | Süper Lig · Türkiye |
| 2019-04-21 | PSV EindhovenvDen HaagEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2019-04-21 | HibernianvCelticPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2019-04-21 | Sturm GrazvWolfsberger ACAustrian Bundesliga · Austria | 1–2 | Austrian Bundesliga · Austria |
| 2019-04-21 | PanetolikosvArisSuper League Greece · Greece | 1–2 | Super League Greece · Greece |
| 2019-04-21 | Spartak MoscowvYeniseyRussian Premier League · Russia | 2–0 | Russian Premier League · Russia |
| 2019-04-21 | Jiangsu SuningvGuangzhou R&FChinese Super League · China | 5–1 | Chinese Super League · China |
| 2019-04-21 | La CorunavExtremadura UDLaLiga 2 · Spain | 1–2 | LaLiga 2 · Spain |
| 2019-04-21 | HorsensvSonderjyskeDanish Superliga · Denmark | 0–1 | Danish Superliga · Denmark |
| 2019-04-21 | NantesvAmiensLigue 1 · France | 3–2 | Ligue 1 · France |
| 2019-04-21 | HackenvDjurgardenAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2019-04-21 | TenerifevAlmeriaLaLiga 2 · Spain | 1–3 | LaLiga 2 · Spain |
| 2019-04-21 | For SittardvNAC BredaEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2019-04-21 | TolucavClub AmericaLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2019-04-21 | AtromitosvPanathinaikosSuper League Greece · Greece | 2–0 | Super League Greece · Greece |
| 2019-04-21 | FreiburgvDortmundBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2019-04-21 | San Jose EarthquakesvSporting Kansas CityMLS · United States | 4–1 | MLS · United States |
| 2019-04-21 | PanioniosvGianninaSuper League Greece · Greece | 2–1 | Super League Greece · Greece |
| 2019-04-21 | EvertonvMan UnitedPremier League · England | 4–0 | Premier League · England |
| 2019-04-21 | DarmstadtvBochum2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2019-04-21 | OFI CretevAsteras TripolisSuper League Greece · Greece | 1–1 | Super League Greece · Greece |
| 2019-04-21 | Tigres UANLvMonarcasLiga MX · Mexico | 3–3 | Liga MX · Mexico |
| 2019-04-21 | St. PoltenvSalzburgAustrian Bundesliga · Austria | 1–1 | Austrian Bundesliga · Austria |
| 2019-04-21 | ReimsvSt EtienneLigue 1 · France | 0–2 | Ligue 1 · France |
| 2019-04-21 | BetisvValenciaLaLiga · Spain | 1–2 | LaLiga · Spain |
| 2019-04-21 | ToulousevLilleLigue 1 · France | 0–0 | Ligue 1 · France |
| 2019-04-21 | CardiffvLiverpoolPremier League · England | 0–2 | Premier League · England |
| 2019-04-21 | AnkaragucuvKonyasporSüper Lig · Türkiye | 0–0 | Süper Lig · Türkiye |
| 2019-04-21 | VejlevAarhusDanish Superliga · Denmark | 2–4 | Danish Superliga · Denmark |
| 2019-04-21 | ArsenalvCrystal PalacePremier League · England | 2–3 | Premier League · England |
| 2019-04-21 | OviedovCordobaLaLiga 2 · Spain | 3–3 | LaLiga 2 · Spain |
| 2019-04-21 | DC UnitedvNew York CityMLS · United States | 0–2 | MLS · United States |
| 2019-04-21 | DresdenvFC Koln2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2019-04-21 | GetafevSevillaLaLiga · Spain | 3–0 | LaLiga · Spain |
| 2019-04-21 | Gaz Metan MediasvCalarasiLiga I · Romania | 0–0 | Liga I · Romania |
| 2019-04-21 | ArbroathvRaith RvsLeague One · Scotland | 2–2 | League One · Scotland |
| 2019-04-21 | AEKvLarisaSuper League Greece · Greece | 0–1 | Super League Greece · Greece |