| 2016-04-11 | BresciavPerugiaSerie B · Italy | 2–2 | Serie B · Italy |
| 2016-04-11 | New York CityvChicago FireMLS · United States | 0–0 | MLS · United States |
| 2016-04-11 | La CorunavLas PalmasLa Liga · Spain | 1–3 | La Liga · Spain |
| 2016-04-10 | AEKvPanioniosSuper League · Greece | 2–0 | Super League · Greece |
| 2016-04-10 | PanthrakikosvIraklisSuper League · Greece | 0–3 | Super League · Greece |
| 2016-04-10 | New York Red BullsvSporting Kansas CityMLS · United States | 0–2 | MLS · United States |
| 2016-04-10 | TorinovAtalantaSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-04-10 | Mersin Idman YurduvGenclerbirligiSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2016-04-10 | LiverpoolvStokePremier League · England | 4–1 | Premier League · England |
| 2016-04-10 | HobrovAalborgSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2016-04-10 | Pacos FerreiravPortoPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2016-04-10 | HeerenveenvAZ AlkmaarEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2016-04-10 | PachucavTigres UANLLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2016-04-10 | Houston DynamovSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2016-04-10 | FalkenbergsvOstersundsAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2016-04-10 | GianninavPlataniasSuper League · Greece | 2–0 | Super League · Greece |
| 2016-04-10 | Lillev MonacoLigue 1 · France | 4–1 | Ligue 1 · France |
| 2016-04-10 | SalzburgvAdmiraBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2016-04-10 | GroningenvGraafschapEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2016-04-10 | Albirex NiigatavIwataJ1 League · Japan | 1–2 | J1 League · Japan |
| 2016-04-10 | BaselvZurichSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2016-04-10 | Dorados de SinaloavCruz AzulLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2016-04-10 | Real Salt LakevColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2016-04-10 | OsasunavElcheLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-04-10 | Vissel KobevAvispa FukuokaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2016-04-10 | HammarbyvHelsingborgAllsvenskan · Sweden | 5–1 | Allsvenskan · Sweden |
| 2016-04-10 | Kashima AntlersvSanfrecce HiroshimaJ1 League · Japan | 4–1 | J1 League · Japan |
| 2016-04-10 | PalermovLazioSerie A · Italy | 0–3 | Serie A · Italy |
| 2016-04-10 | NurnbergvDuisburg2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2016-04-10 | Nagoya GrampusvOmiya ArdijaJ1 League · Japan | 1–2 | J1 League · Japan |
| 2016-04-10 | NacionalvEstorilPrimeira Liga · Portugal | 4–1 | Primeira Liga · Portugal |
| 2016-04-10 | Asteras TripolisvPanathinaikosSuper League · Greece | 0–0 | Super League · Greece |
| 2016-04-10 | Kashiwa ReysolvFC TokyoJ1 League · Japan | 1–0 | J1 League · Japan |
| 2016-04-10 | KaiserslauternvKarlsruhe2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2016-04-10 | StartvMoldeEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2016-04-10 | FreiburgvSt Pauli2. Bundesliga · Germany | 4–3 | 2. Bundesliga · Germany |
| 2016-04-10 | Argentinos JrsvNewells Old BoysLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2016-04-10 | AldosivivRacing ClubLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2016-04-10 | KalmarvElfsborgAllsvenskan · Sweden | 3–2 | Allsvenskan · Sweden |
| 2016-04-10 | FCSBvDin. BucurestiSuperliga · Romania | 1–1 | Superliga · Romania |
| 2016-04-10 | BrondbyvOdenseSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2016-04-10 | PanetolikosvOlympiakosSuper League · Greece | 2–5 | Super League · Greece |
| 2016-04-10 | ValenciavSevillaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2016-04-10 | Rosario CentralvVelez SarsfieldLiga Profesional · Argentina | 2–3 | Liga Profesional · Argentina |
| 2016-04-10 | MarseillevBordeauxLigue 1 · France | 0–0 | Ligue 1 · France |
| 2016-04-10 | VeriavXanthiSuper League · Greece | 1–1 | Super League · Greece |
| 2016-04-10 | NicevRennesLigue 1 · France | 3–0 | Ligue 1 · France |
| 2016-04-10 | CordobavAlbaceteLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2016-04-10 | Shanghai SIPGvLiaoningSuper League · China | 4–0 | Super League · China |
| 2016-04-10 | FC KolnvLeverkusenBundesliga · Germany | 0–2 | Bundesliga · Germany |