| 2022-04-16 | AlanyasporvAntalyasporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2022-04-16 | UfavCSKA MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2022-04-16 | AltachvLASKBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2022-04-16 | RotherhamvIpswichLeague One · England | 1–0 | League One · England |
| 2022-04-15 | KuPSvSJKVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2022-04-15 | WokingvTorquayNational League · England | 0–1 | National League · England |
| 2022-04-15 | Derry CityvShelbournePremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2022-04-15 | WalsallvCarlisleLeague Two · England | 1–0 | League Two · England |
| 2022-04-15 | FamalicaovGil VicentePrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2022-04-15 | EibarvLas PalmasLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2022-04-15 | StevenagevRochdaleLeague Two · England | 1–0 | League Two · England |
| 2022-04-15 | AltrinchamvHalifaxNational League · England | 1–1 | National League · England |
| 2022-04-15 | Rennesv MonacoLigue 1 · France | 2–3 | Ligue 1 · France |
| 2022-04-15 | Fleetwood TownvOxfordLeague One · England | 2–3 | League One · England |
| 2022-04-15 | LutonvNott'm ForestChampionship · England | 1–0 | Championship · England |
| 2022-04-15 | OldhamvNorthamptonLeague Two · England | 0–2 | League Two · England |
| 2022-04-15 | Gimnasia L.P.vSarmiento JuninCopa De La Liga Profesional · Argentina | 1–3 | Copa De La Liga Profesional · Argentina |
| 2022-04-15 | SwanseavBarnsleyChampionship · England | 1–1 | Championship · England |
| 2022-04-15 | UC DublinvDroghedaPremier Division · Ireland | 0–2 | Premier Division · Ireland |
| 2022-04-15 | Dynamo MoscowvAkhmat GroznyPremier League · Russia | 2–0 | Premier League · Russia |
| 2022-04-15 | TrabzonsporvKaragumrukSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-04-15 | HullvCardiffChampionship · England | 2–1 | Championship · England |
| 2022-04-15 | TigrevHuracanCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-15 | WycombevPlymouthLeague One · England | 2–0 | League One · England |
| 2022-04-15 | Boreham WoodvDover AthleticNational League · England | 1–2 | National League · England |
| 2022-04-15 | BarrowvForest GreenLeague Two · England | 4–0 | League Two · England |
| 2022-04-15 | Leyton OrientvScunthorpeLeague Two · England | 3–0 | League Two · England |
| 2022-04-15 | Sheffield UnitedvReadingChampionship · England | 1–2 | Championship · England |
| 2022-04-15 | MansfieldvSuttonLeague Two · England | 2–3 | League Two · England |
| 2022-04-15 | CrewevAFC WimbledonLeague One · England | 3–1 | League One · England |
| 2022-04-15 | MiovenivDin. BucurestiSuperliga · Romania | 2–0 | Superliga · Romania |
| 2022-04-15 | GrimsbyvStockportNational League · England | 2–1 | National League · England |
| 2022-04-15 | Notts CountyvKings LynnNational League · England | 4–1 | National League · England |
| 2022-04-15 | Dag and RedvBarnetNational League · England | 7–3 | National League · England |
| 2022-04-15 | PortsmouthvLincolnLeague One · England | 3–2 | League One · England |
| 2022-04-15 | Central CordobavArsenal SarandiCopa De La Liga Profesional · Argentina | 3–3 | Copa De La Liga Profesional · Argentina |
| 2022-04-15 | PrestonvMillwallChampionship · England | 1–1 | Championship · England |
| 2022-04-15 | SociedadvBetisLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-04-15 | DerbyvFulhamChampionship · England | 2–1 | Championship · England |
| 2022-04-15 | NordsjaellandvSonderjyskeSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2022-04-15 | BirminghamvCoventryChampionship · England | 2–4 | Championship · England |
| 2022-04-15 | EastleighvBromleyNational League · England | 0–2 | National League · England |
| 2022-04-15 | AccringtonvBurtonLeague One · England | 0–0 | League One · England |
| 2022-04-15 | Bristol RvsvSalfordLeague Two · England | 1–0 | League Two · England |
| 2022-04-15 | HarrogatevSwindonLeague Two · England | 1–4 | League Two · England |
| 2022-04-15 | AmorebietavMirandesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-04-15 | WrexhamvSolihullNational League · England | 1–1 | National League · England |
| 2022-04-15 | GuimaraesvPacos FerreiraPrimeira Liga · Portugal | 4–0 | Primeira Liga · Portugal |
| 2022-04-15 | BradfordvTranmereLeague Two · England | 1–1 | League Two · England |
| 2022-04-15 | AtlasvMazatlan FCLiga MX · Mexico | 1–2 | Liga MX · Mexico |