| 2022-04-16 | FC VoluntarivFC ArgesSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-04-16 | WiganvCambridgeLeague One · England | 1–2 | League One · England |
| 2022-04-16 | VarbergvSundsvallAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2022-04-16 | GetafevVillarrealLa Liga · Spain | 1–2 | La Liga · Spain |
| 2022-04-16 | Atlanta UtdvFC CincinnatiMLS · United States | 0–0 | MLS · United States |
| 2022-04-16 | Cove RangersvAlloaLeague One · Scotland | 3–0 | League One · Scotland |
| 2022-04-16 | NecaxavAtl. San LuisLiga MX · Mexico | 4–2 | Liga MX · Mexico |
| 2022-04-16 | RodezvParis FCLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-04-16 | PartickvRaith RvsChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-04-16 | CartagenavAlcorconLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2022-04-16 | StirlingvElginLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2022-04-16 | TottenhamvBrightonPremier League · England | 0–1 | Premier League · England |
| 2022-04-16 | LeganesvMalagaLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2022-04-16 | Barracas CentralvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 1–6 | Copa De La Liga Profesional · Argentina |
| 2022-04-16 | StenhousemuirvAlbion RvsLeague Two · Scotland | 4–1 | League Two · Scotland |
| 2022-04-16 | NancyvNiortLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-04-16 | ToulousevQuevilly RouenLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-04-16 | ValladolidvAlmeriaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2022-04-16 | Farul ConstantavUniv. CraiovaSuperliga · Romania | 0–3 | Superliga · Romania |
| 2022-04-16 | LaziovTorinoSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-04-16 | HartbergvAdmiraBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2022-04-16 | ZurichvYoung BoysSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2022-04-16 | ArbroathvQueen of SthChampionship · Scotland | 5–1 | Championship · Scotland |
| 2022-04-16 | SandhausenvSt Pauli2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-16 | DijonvAjaccioLigue 2 · France | 0–3 | Ligue 2 · France |
| 2022-04-16 | StranraervKelty HeartsLeague Two · Scotland | 0–3 | League Two · Scotland |
| 2022-04-16 | For SittardvSparta RotterdamEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2022-04-16 | CowdenbeathvEdinburgh CityLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-04-16 | FiorentinavVeneziaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-04-16 | CF MontrealvVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-04-16 | MaritimovBoavistaPrimeira Liga · Portugal | 4–0 | Primeira Liga · Portugal |
| 2022-04-16 | ClydevMontroseLeague One · Scotland | 2–1 | League One · Scotland |
| 2022-04-16 | FreiburgvBochumBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-04-16 | HataysporvSivassporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-04-16 | LecznavRadomiak RadomEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-04-16 | JuarezvPachucaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2022-04-16 | PeterheadvQueens ParkLeague One · Scotland | 2–1 | League One · Scotland |
| 2022-04-16 | DortmundvWolfsburgBundesliga · Germany | 6–1 | Bundesliga · Germany |
| 2022-04-16 | AltayvBuyuksehyrSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-04-16 | ApollonvVolos NFCSuper League · Greece | 1–1 | Super League · Greece |
| 2022-04-16 | DjurgardenvNorrkopingAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2022-04-16 | JagielloniavPogon SzczecinEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2022-04-16 | ValenciavOsasunaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2022-04-16 | ElchevMallorcaLa Liga · Spain | 3–0 | La Liga · Spain |
| 2022-04-16 | Stal MielecvWarta PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-04-16 | BelenensesvVizelaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-04-16 | San Jose EarthquakesvNashville SCMLS · United States | 2–2 | MLS · United States |
| 2022-04-16 | Pau FCvAuxerreLigue 2 · France | 1–4 | Ligue 2 · France |
| 2022-04-16 | MoreirensevTondelaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-04-16 | CaenvAmiensLigue 2 · France | 1–1 | Ligue 2 · France |