| 2021-04-30 | PortovFamalicaoPrimeira Liga · Portugal | 3–2 | Primeira Liga · Portugal |
| 2021-04-30 | Atl. San LuisvPachucaLiga MX · Mexico | 1–5 | Liga MX · Mexico |
| 2021-04-30 | GuimaraesvMoreirensePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-04-30 | BohemiansvDerry CityPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2021-04-29 | Wuhan FCvShanghai ShenhuaSuper League · China | 1–3 | Super League · China |
| 2021-04-29 | Din. BucurestivFC VoluntariSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-04-29 | BarcelonavGranadaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-04-29 | ForfarvClydeLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-04-29 | Queens ParkvEdinburgh CityLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-04-29 | HamburgvKarlsruhe2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-04-29 | Univ. CraiovavFCSBSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-04-29 | ElginvStirlingLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2021-04-29 | MaritimovSp BragaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-04-29 | MontrosevCove RangersLeague One · Scotland | 0–2 | League One · Scotland |
| 2021-04-29 | Erzurum BBvBuyuksehyrSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-04-29 | Changchun YataivTianjin Jinmen TigerSuper League · China | 0–0 | Super League · China |
| 2021-04-29 | Poli IasivViitorul ConstantaSuperliga · Romania | 0–3 | Superliga · Romania |
| 2021-04-29 | Nagoya GrampusvKawasaki FrontaleJ1 League · Japan | 0–4 | J1 League · Japan |
| 2021-04-29 | AnkaragucuvGaziantepSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-04-29 | BrechinvAnnan AthleticLeague Two · Scotland | 0–3 | League Two · Scotland |
| 2021-04-29 | AlanyasporvFenerbahceSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-29 | East FifevPeterheadLeague One · Scotland | 1–3 | League One · Scotland |
| 2021-04-29 | PartickvFalkirkLeague One · Scotland | 5–0 | League One · Scotland |
| 2021-04-29 | SivassporvYeni MalatyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-04-29 | StenhousemuirvAlbion RvsLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-04-28 | LASKvSturm GrazBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-04-28 | Greuther FurthvSandhausen2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-04-28 | Chindia TargovistevAstraSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-04-28 | DunkerquevAmiensLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-28 | Sepsi Sf. GheorghevAcademica ClinceniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-04-28 | Dalian ProvHebeiSuper League · China | 0–1 | Super League · China |
| 2021-04-28 | KayserisporvDenizlisporSüper Lig · Turkey | 6–3 | Süper Lig · Turkey |
| 2021-04-28 | RizesporvBesiktasSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-04-28 | Ath BilbaovValladolidLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-04-28 | TirolvSK RapidBundesliga · Austria | 2–3 | Bundesliga · Austria |
| 2021-04-28 | GoztepvTrabzonsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-28 | JagielloniavRakowEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-04-28 | CFR ClujvFC BotosaniSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-04-28 | SalzburgvWolfsberger ACBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-04-28 | Shanghai PortvBeijing GuoanSuper League · China | 3–1 | Super League · China |
| 2021-04-28 | GalatasarayvKonyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-04-28 | KaragumrukvAntalyasporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-04-27 | Forest GreenvBarrowLeague Two · England | 0–2 | League Two · England |
| 2021-04-27 | Annan AthleticvStenhousemuirLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-04-27 | CheltenhamvCarlisleLeague Two · England | 1–1 | League Two · England |
| 2021-04-27 | FarensevPortimonensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-04-27 | PachucavSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-04-27 | EmpolivChievoSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-04-27 | StranraervElginLeague Two · Scotland | 1–4 | League Two · Scotland |
| 2021-04-27 | BradfordvSalfordLeague Two · England | 0–1 | League Two · England |