| 2022-04-17 | NewcastlevLeicesterPremier League · England | 2–1 | Premier League · England |
| 2022-04-17 | UNAM PumasvMonterreyLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-04-17 | KalmarvDegerforsAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2022-04-16 | America MGvJuventudeSerie A · Brazil | 4–1 | Serie A · Brazil |
| 2022-04-16 | MortonvHamiltonChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-04-16 | RiedvTirolBundesliga · Austria | 2–3 | Bundesliga · Austria |
| 2022-04-16 | Colon Santa FEvIndependienteCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-16 | Sepsi Sf. GheorghevUTA AradSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-04-16 | Newells Old BoysvPatronatoCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-16 | Man UnitedvNorwichPremier League · England | 3–2 | Premier League · England |
| 2022-04-16 | UdinesevEmpoliSerie A · Italy | 4–1 | Serie A · Italy |
| 2022-04-16 | LillevLensLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-04-16 | NimesvSochauxLigue 2 · France | 1–3 | Ligue 2 · France |
| 2022-04-16 | Houston DynamovPortland TimbersMLS · United States | 0–0 | MLS · United States |
| 2022-04-16 | CagliarivSassuoloSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-04-16 | San LorenzovPlatenseCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-16 | SouthamptonvArsenalPremier League · England | 1–0 | Premier League · England |
| 2022-04-16 | GoiasvPalmeirasSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2022-04-16 | Airdrie UtdvDumbartonLeague One · Scotland | 3–2 | League One · Scotland |
| 2022-04-16 | Club TijuanavClub AmericaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2022-04-16 | Termalica B-B.vRakowEkstraklasa · Poland | 0–3 | Ekstraklasa · Poland |
| 2022-04-16 | HamburgvKarlsruhe2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-04-16 | BastiavGuingampLigue 2 · France | 1–2 | Ligue 2 · France |
| 2022-04-16 | FenerbahcevGoztepSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2022-04-16 | ZenitvUralPremier League · Russia | 3–1 | Premier League · Russia |
| 2022-04-16 | M'gladbachvFC KolnBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2022-04-16 | WatfordvBrentfordPremier League · England | 1–2 | Premier League · England |
| 2022-04-16 | DresdenvHolstein Kiel2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-04-16 | Wisla PlockvLech PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-04-16 | Hokkaido Consadole SapporovFC TokyoJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-04-16 | PortovPortimonensePrimeira Liga · Portugal | 7–0 | Primeira Liga · Portugal |
| 2022-04-16 | AlavesvVallecanoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-04-16 | Milton Keynes DonsvSheffield WedsLeague One · England | 2–3 | League One · England |
| 2022-04-16 | HannovervFortuna Dusseldorf2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-04-16 | ServettevGrasshoppersSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2022-04-16 | ValenciennesvLe HavreLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-04-16 | SampdoriavSalernitanaSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-04-16 | Club LeonvPueblaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-16 | St EtiennevBrestLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-16 | East FifevFalkirkLeague One · Scotland | 1–3 | League One · Scotland |
| 2022-04-16 | MainzvStuttgartBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-04-16 | ForfarvAnnan AthleticLeague Two · Scotland | 5–1 | League Two · Scotland |
| 2022-04-16 | Spartak MoscowvRubin KazanPremier League · Russia | 1–1 | Premier League · Russia |
| 2022-04-16 | AugsburgvHerthaBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-04-16 | CorinthiansvAvaiSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2022-04-16 | PanetolikosvAsteras TripolisSuper League · Greece | 0–0 | Super League · Greece |
| 2022-04-16 | DunkerquevGrenobleLigue 2 · France | 0–3 | Ligue 2 · France |
| 2022-04-16 | Sp GijonvOviedoLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2022-04-16 | JuventusvBolognaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-04-16 | DunfermlinevAyrChampionship · Scotland | 2–1 | Championship · Scotland |