| 2021-05-01 | Crystal PalacevMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-05-01 | Houston DynamovLos Angeles FCMLS · United States | 1–1 | MLS · United States |
| 2021-05-01 | Paris FCvToulouseLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-05-01 | Yokohama FCvKashima AntlersJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-05-01 | Vissel KobevSanfrecce HiroshimaJ1 League · Japan | 3–0 | J1 League · Japan |
| 2021-05-01 | VaduzvLuzernSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-05-01 | HeraclesvVVV VenloEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2021-05-01 | Rubin KazanvDynamo MoscowPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-05-01 | LegiavWislaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-05-01 | WalsallvMorecambeLeague Two · England | 0–2 | League Two · England |
| 2021-05-01 | HuddersfieldvCoventryChampionship · England | 1–1 | Championship · England |
| 2021-05-01 | Club LeonvQueretaroLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-05-01 | St MirrenvHamiltonPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-05-01 | WokingvWeymouthNational League · England | 2–4 | National League · England |
| 2021-05-01 | SiriusvKalmarAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-01 | VeneziavChievoSerie B · Italy | 3–1 | Serie B · Italy |
| 2021-05-01 | AlmeriavOviedoLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-05-01 | StevenagevCrawley TownLeague Two · England | 3–3 | League Two · England |
| 2021-05-01 | Paris SGvLensLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-05-01 | HalifaxvStockportNational League · England | 0–1 | National League · England |
| 2021-05-01 | ColchestervSalfordLeague Two · England | 1–0 | League Two · England |
| 2021-05-01 | R. VolgogradvAkhmat GroznyPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-05-01 | PlymouthvSunderlandLeague One · England | 1–3 | League One · England |
| 2021-05-01 | Virtus EntellavVicenzaSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-05-01 | Annan AthleticvCowdenbeathLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-05-01 | BirminghamvCardiffChampionship · England | 0–4 | Championship · England |
| 2021-05-01 | HartlepoolvChesterfieldNational League · England | 3–1 | National League · England |
| 2021-05-01 | LutonvMiddlesbroughChampionship · England | 1–1 | Championship · England |
| 2021-04-30 | HarrogatevCambridgeLeague Two · England | 5–4 | League Two · England |
| 2021-04-30 | TondelavBenficaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-04-30 | AlloavDunfermlineChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-04-30 | DroghedavSligo RoversPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-04-30 | Inverness CvAyrChampionship · Scotland | 2–2 | Championship · Scotland |
| 2021-04-30 | WaterfordvDundalkPremier Division · Ireland | 0–3 | Premier Division · Ireland |
| 2021-04-30 | Pacos FerreiravBelenensesPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-04-30 | St. PatricksvLongfordPremier Division · Ireland | 3–0 | Premier Division · Ireland |
| 2021-04-30 | Wisla PlockvLechia GdanskEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-04-30 | Queen of SthvDundeeChampionship · Scotland | 0–2 | Championship · Scotland |
| 2021-04-30 | SouthamptonvLeicesterPremier League · England | 1–1 | Premier League · England |
| 2021-04-30 | MarseillevStrasbourgLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-04-30 | CeltavLevanteLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-04-30 | Gaz Metan MediasvFC ArgesSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-04-30 | Slask WroclawvZaglebieEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-04-30 | HorsensvVejleSuperliga · Denmark | 3–3 | Superliga · Denmark |
| 2021-04-30 | ArbroathvMortonChampionship · Scotland | 0–0 | Championship · Scotland |
| 2021-04-30 | AalborgvLyngbySuperliga · Denmark | 4–0 | Superliga · Denmark |
| 2021-04-30 | Velez SarsfieldvPatronatoCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-30 | Raith RvsvHeartsChampionship · Scotland | 0–4 | Championship · Scotland |
| 2021-04-30 | Finn HarpsvShamrock RoversPremier Division · Ireland | 0–2 | Premier Division · Ireland |
| 2021-04-30 | LugovZaragozaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |