| 2016-04-16 | RodavPSV EindhovenEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2016-04-16 | ShrewsburyvBradfordLeague One · England | 1–1 | League One · England |
| 2016-04-16 | Las PalmasvSp GijonLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-04-16 | AroucavRio AvePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2016-04-16 | CagliarivBresciaSerie B · Italy | 6–0 | Serie B · Italy |
| 2016-04-16 | SwindonvBuryLeague One · England | 0–1 | League One · England |
| 2016-04-16 | TranmerevWrexhamNational League · England | 1–2 | National League · England |
| 2016-04-16 | RochdalevBlackpoolLeague One · England | 3–0 | League One · England |
| 2016-04-16 | FeyenoordvGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2016-04-16 | LongfordvDerry CityPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2016-04-16 | Union de Santa FevTigreLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2016-04-16 | BarivComoSerie B · Italy | 3–0 | Serie B · Italy |
| 2016-04-16 | BoltonvMiddlesbroughChampionship · England | 1–2 | Championship · England |
| 2016-04-16 | SionvGrasshoppersSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2016-04-16 | WycombevBarnetLeague Two · England | 1–1 | League Two · England |
| 2016-04-16 | St PaulivBochum2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2016-04-16 | Urawa RedsvVegalta SendaiJ1 League · Japan | 3–1 | J1 League · Japan |
| 2016-04-16 | West BromvWatfordPremier League · England | 0–1 | Premier League · England |
| 2016-04-16 | CambridgevCarlisleLeague Two · England | 0–0 | League Two · England |
| 2016-04-16 | StromsgodsetvSogndalEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2016-04-16 | AstravFCSBSuperliga · Romania | 2–0 | Superliga · Romania |
| 2016-04-16 | BastiavSt EtienneLigue 1 · France | 0–1 | Ligue 1 · France |
| 2016-04-16 | RosenborgvBrannEliteserien · Norway | 3–0 | Eliteserien · Norway |
| 2016-04-16 | CrewevScunthorpeLeague One · England | 2–3 | League One · England |
| 2016-04-16 | Ajaccio GFCOvLilleLigue 1 · France | 2–4 | Ligue 1 · France |
| 2016-04-16 | WalsallvSouthendLeague One · England | 1–0 | League One · England |
| 2016-04-16 | Atl. TucumanvDefensa y JusticiaLiga Profesional · Argentina | 3–1 | Liga Profesional · Argentina |
| 2016-04-16 | QueretarovClub AmericaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2016-04-16 | ChestervWelling UnitedNational League · England | 4–0 | National League · England |
| 2016-04-16 | Le HavrevNancyLigue 2 · France | 1–3 | Ligue 2 · France |
| 2016-04-16 | BirminghamvBurnleyChampionship · England | 1–2 | Championship · England |
| 2016-04-16 | AZ AlkmaarvZwolleEredivisie · Netherlands | 5–1 | Eredivisie · Netherlands |
| 2016-04-16 | AdmiravGrodigBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2016-04-16 | StranraervDunfermlineLeague One · Scotland | 4–1 | League One · Scotland |
| 2016-04-16 | NumanciavLlagosteraLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-04-16 | St MirrenvMortonChampionship · Scotland | 3–1 | Championship · Scotland |
| 2016-04-16 | Boca JuniorsvAldosiviLiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2016-04-16 | ClydevEast FifeLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2016-04-16 | Omiya ArdijavKofuJ1 League · Japan | 1–1 | J1 League · Japan |
| 2016-04-16 | LiaoningvTianjin Jinmen TigerSuper League · China | 2–2 | Super League · China |
| 2016-04-16 | MoreirensevSp LisbonPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2016-04-16 | DoncastervWiganLeague One · England | 3–1 | League One · England |
| 2016-04-16 | FC TokyovKawasaki FrontaleJ1 League · Japan | 2–4 | J1 League · Japan |
| 2016-04-16 | BlackburnvHuddersfieldChampionship · England | 0–2 | Championship · England |
| 2016-04-16 | ColchestervPeterboroLeague One · England | 1–4 | League One · England |
| 2016-04-16 | ChesterfieldvSheffield UnitedLeague One · England | 0–3 | League One · England |
| 2016-04-16 | CharltonvDerbyChampionship · England | 0–1 | Championship · England |
| 2016-04-16 | Sturm GrazvWolfsberger ACBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2016-04-16 | BolognavTorinoSerie A · Italy | 0–1 | Serie A · Italy |
| 2016-04-16 | RizesporvOsmanlisporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |