| 2022-04-17 | Union BerlinvEin FrankfurtBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-04-17 | U Craiova 1948vAcademica ClinceniSuperliga · Romania | 4–0 | Superliga · Romania |
| 2022-04-17 | Arsenal TulavFK RostovPremier League · Russia | 1–2 | Premier League · Russia |
| 2022-04-17 | Defensa y JusticiavAtl. TucumanCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-17 | Minnesota UnitedvColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2022-04-17 | Sagan TosuvShimizu S-PulseJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-04-17 | New York CityvReal Salt LakeMLS · United States | 6–0 | MLS · United States |
| 2022-04-17 | Argentinos JrsvTalleres CordobaCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-17 | Kashima AntlersvNagoya GrampusJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-04-17 | ElfsborgvVarnamoAllsvenskan · Sweden | 4–1 | Allsvenskan · Sweden |
| 2022-04-17 | Columbus CrewvOrlando CityMLS · United States | 0–2 | MLS · United States |
| 2022-04-17 | Flamengo RJvSao PauloSerie A · Brazil | 3–1 | Serie A · Brazil |
| 2022-04-17 | HuescavZaragozaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-04-17 | CuiabavFluminenseSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-04-17 | MetzvClermontLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-04-17 | Sturm GrazvSK RapidBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2022-04-17 | InternacionalvFortalezaSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2022-04-17 | Hansa RostockvRegensburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-17 | AC OuluvIlvesVeikkausliiga · Finland | 2–2 | Veikkausliiga · Finland |
| 2022-04-17 | Austria ViennavSalzburgBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2022-04-17 | SevillavReal MadridLa Liga · Spain | 2–3 | La Liga · Spain |
| 2022-04-17 | Kashiwa ReysolvKyotoJ1 League · Japan | 0–2 | J1 League · Japan |
| 2022-04-17 | Ath MadridvEspanolLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-04-17 | Tigres UANLvTolucaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2022-04-17 | SantosvCoritibaSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2022-04-17 | Ath BilbaovCeltaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2022-04-17 | GiresunsporvBesiktasSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-04-17 | LeverkusenvRB LeipzigBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-04-17 | New England RevolutionvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-04-17 | MontpelliervReimsLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-04-17 | Gamba OsakavShonan BellmareJ1 League · Japan | 0–1 | J1 League · Japan |
| 2022-04-17 | Toronto FCvPhiladelphia UnionMLS · United States | 2–1 | MLS · United States |
| 2022-04-17 | HoffenheimvGreuther FurthBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-04-17 | Sp LisbonvBenficaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2022-04-17 | Krylya SovetovvKrasnodarPremier League · Russia | 2–0 | Premier League · Russia |
| 2022-04-17 | Malmo FFvAIKAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2022-04-17 | KasimpasavAd. DemirsporSüper Lig · Turkey | 4–0 | Süper Lig · Turkey |
| 2022-04-17 | HackenvGoteborgAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2022-04-17 | BragantinovAtletico GOSerie A · Brazil | 4–0 | Serie A · Brazil |
| 2022-04-17 | NantesvAngersLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-04-17 | CFR ClujvFCSBSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-04-17 | Racing ClubvUnion de Santa FeCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-17 | KonyasporvGaziantepSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2022-04-17 | BielefeldvBayern MunichBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2022-04-17 | New York Red BullsvFC DallasMLS · United States | 0–0 | MLS · United States |
| 2022-04-17 | PanathinaikosvOlympiakosSuper League · Greece | 1–0 | Super League · Greece |
| 2022-04-17 | TenerifevFuenlabradaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2022-04-17 | Santos LagunavQueretaroLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-04-17 | Inter TurkuvHakaVeikkausliiga · Finland | 0–2 | Veikkausliiga · Finland |
| 2022-04-17 | Boca JuniorsvLanusCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |