| 2021-05-01 | ClydevDumbartonLeague One · Scotland | 2–0 | League One · Scotland |
| 2021-05-01 | WycombevBournemouthChampionship · England | 1–0 | Championship · England |
| 2021-05-01 | ChelseavFulhamPremier League · England | 2–0 | Premier League · England |
| 2021-05-01 | PortimonensevRio AvePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-05-01 | Sheffield WedsvNott'm ForestChampionship · England | 0–0 | Championship · England |
| 2021-05-01 | MotherwellvKilmarnockPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-05-01 | Vegalta SendaivKashiwa ReysolJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-05-01 | FalkirkvMontroseLeague One · Scotland | 1–2 | League One · Scotland |
| 2021-05-01 | Edinburgh CityvElginLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-05-01 | CosenzavPescaraSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-05-01 | Lech PoznanvStal MielecEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-05-01 | PeterborovLincolnLeague One · England | 3–3 | League One · England |
| 2021-05-01 | CaenvAuxerreLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-05-01 | Leyton OrientvCarlisleLeague Two · England | 2–3 | League Two · England |
| 2021-05-01 | ReggianavPordenoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-05-01 | PrestonvBarnsleyChampionship · England | 2–0 | Championship · England |
| 2021-05-01 | Albion RvsvBrechinLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-05-01 | VeronavSpeziaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-01 | Pau FCvAjaccioLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-05-01 | HuescavSociedadLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-05-01 | MallorcavMirandesLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-05-01 | New York Red BullsvChicago FireMLS · United States | 2–0 | MLS · United States |
| 2021-05-01 | StirlingvStranraerLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2021-05-01 | Gil VicentevFarensePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-05-01 | Cove RangersvAirdrie UtdLeague One · Scotland | 0–2 | League One · Scotland |
| 2021-05-01 | BradfordvScunthorpeLeague Two · England | 0–0 | League Two · England |
| 2021-05-01 | LivingstonvAberdeenPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-05-01 | AscolivEmpoliSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-05-01 | Sp LisbonvNacionalPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-05-01 | WrexhamvSolihullNational League · England | 2–1 | National League · England |
| 2021-05-01 | FrosinonevPisaSerie B · Italy | 3–1 | Serie B · Italy |
| 2021-05-01 | SalernitanavMonzaSerie B · Italy | 1–3 | Serie B · Italy |
| 2021-05-01 | NorwichvReadingChampionship · England | 4–1 | Championship · England |
| 2021-05-01 | MillwallvBristol CityChampionship · England | 4–1 | Championship · England |
| 2021-05-01 | BresciavSpalSerie B · Italy | 3–1 | Serie B · Italy |
| 2021-05-01 | PeterheadvForfarLeague One · Scotland | 1–2 | League One · Scotland |
| 2021-05-01 | FC BotosanivSepsi Sf. GheorgheSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-05-01 | KrasnodarvSochiPremier League · Russia | 1–3 | Premier League · Russia |
| 2021-05-01 | Kings LynnvMaidenheadNational League · England | 0–0 | National League · England |
| 2021-05-01 | ChateaurouxvTroyesLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-05-01 | Real MadridvOsasunaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-05-01 | Bristol RvsvCreweLeague One · England | 0–1 | League One · England |
| 2021-05-01 | BarrowvSouthendLeague Two · England | 1–2 | League Two · England |
| 2021-05-01 | LeccevCittadellaSerie B · Italy | 1–3 | Serie B · Italy |
| 2021-05-01 | Avispa FukuokavUrawa RedsJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-05-01 | JuarezvTolucaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-05-01 | ShrewsburyvOxfordLeague One · England | 2–3 | League One · England |
| 2021-05-01 | HammarbyvHackenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-01 | Sagan TosuvTokushimaJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-05-01 | BrightonvLeedsPremier League · England | 2–0 | Premier League · England |