| 2010-11-20 | SalamancavLas PalmasLa Liga 2 · Spain | 4–2 | La Liga 2 · Spain |
| 2010-11-20 | HeartsvHamiltonPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2010-11-20 | GraafschapvRodaEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2010-11-20 | TwentevAZ AlkmaarEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2010-11-20 | BarnsleyvPortsmouthChampionship · England | 1–0 | Championship · England |
| 2010-11-20 | NicevMontpellierLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-11-20 | ElchevGironaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-11-20 | SochauxvLorientLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-11-20 | CardiffvNott'm ForestChampionship · England | 0–2 | Championship · England |
| 2010-11-20 | Rushden & DvYorkNational League · England | 0–4 | National League · England |
| 2010-11-20 | BesiktasvKonyasporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2010-11-20 | Dag and RedvOldhamLeague One · England | 0–1 | League One · England |
| 2010-11-20 | GimnasticvHuescaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-11-20 | Olympiakos VolouvAsteras TripolisSuper League · Greece | 1–1 | Super League · Greece |
| 2010-11-20 | AtalantavCrotoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-11-20 | MansfieldvHayes & YeadingNational League · England | 3–2 | National League · England |
| 2010-11-20 | RennesvBrestLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-11-20 | EupenvKortrijkPro League · Belgium | 3–1 | Pro League · Belgium |
| 2010-11-20 | Bristol CityvLeicesterChampionship · England | 2–0 | Championship · England |
| 2010-11-20 | GentvWesterloPro League · Belgium | 4–4 | Pro League · Belgium |
| 2010-11-20 | HullvIpswichChampionship · England | 1–0 | Championship · England |
| 2010-11-20 | CartagenavBetisLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2010-11-20 | GerminalvAnderlechtPro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-11-20 | ManisasporvBursasporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2010-11-20 | VillarrealvValenciaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2010-11-20 | AscolivVareseSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-11-20 | CoventryvBurnleyChampionship · England | 1–0 | Championship · England |
| 2010-11-20 | NurnbergvKaiserslauternBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2010-11-20 | SassuolovTriestinaSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-11-20 | St EtiennevAuxerreLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-11-20 | West BromvStokePremier League · England | 0–3 | Premier League · England |
| 2010-11-20 | BoltonvNewcastlePremier League · England | 5–1 | Premier League · England |
| 2010-11-20 | RochdalevSwindonLeague One · England | 3–3 | League One · England |
| 2010-11-20 | AldershotvChesterfieldLeague Two · England | 0–2 | League Two · England |
| 2010-11-20 | PanathinaikosvIraklisSuper League · Greece | 4–2 | Super League · Greece |
| 2010-11-20 | XanthivPanserraikosSuper League · Greece | 2–0 | Super League · Greece |
| 2010-11-20 | CheltenhamvMorecambeLeague Two · England | 1–1 | League Two · England |
| 2010-11-20 | MilanvFiorentinaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-11-20 | Leyton OrientvBournemouthLeague One · England | 2–2 | League One · England |
| 2010-11-20 | ExcelsiorvVVV VenloEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2010-11-20 | GatesheadvForest GreenNational League · England | 1–1 | National League · England |
| 2010-11-20 | AberdeenvSt JohnstonePremiership · Scotland | 0–1 | Premiership · Scotland |
| 2010-11-20 | KasimpasavGenclerbirligiSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2010-11-20 | BirminghamvChelseaPremier League · England | 1–0 | Premier League · England |
| 2010-11-20 | BrightonvBristol RvsLeague One · England | 2–2 | League One · England |
| 2010-11-20 | MiddlesbroughvMillwallChampionship · England | 0–1 | Championship · England |
| 2010-11-20 | Newport CountyvSouthportNational League · England | 2–0 | National League · England |
| 2010-11-20 | DoncastervSwanseaChampionship · England | 1–1 | Championship · England |
| 2010-11-20 | Notts CountyvTranmereLeague One · England | 0–1 | League One · England |
| 2010-11-20 | LeverkusenvBayern MunichBundesliga · Germany | 1–1 | Bundesliga · Germany |