| 2000-11-26 | MurciavAth MadridLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2000-11-26 | LeverkusenvKaiserslauternBundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2000-11-26 | PanahaikivKalamataSuper League · Greece | 3–2 | Super League · Greece |
| 2000-11-26 | AalstvBeverenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2000-11-26 | ValladolidvSociedadLa Liga · Spain | 2–1 | La Liga · Spain |
| 2000-11-26 | NewcastlevLiverpoolPremier League · England | 2–1 | Premier League · England |
| 2000-11-26 | ValenciavOviedoLa Liga · Spain | 2–0 | La Liga · Spain |
| 2000-11-26 | St EtiennevNantesLigue 1 · France | 0–2 | Ligue 1 · France |
| 2000-11-26 | ChievovPescaraSerie B · Italy | 0–2 | Serie B · Italy |
| 2000-11-26 | JuventusvVeronaSerie A · Italy | 2–1 | Serie A · Italy |
| 2000-11-26 | CagliarivCittadellaSerie B · Italy | 3–0 | Serie B · Italy |
| 2000-11-26 | KocaelisporvYozgatsporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2000-11-26 | SedanvBordeauxLigue 1 · France | 0–0 | Ligue 1 · France |
| 2000-11-26 | GalatasarayvFenerbahceSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2000-11-26 | NijmegenvHeerenveenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2000-11-26 | BursasporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2000-11-26 | TernanavVeneziaSerie B · Italy | 3–1 | Serie B · Italy |
| 2000-11-26 | SienavMonzaSerie B · Italy | 3–1 | Serie B · Italy |
| 2000-11-26 | AlbacetevJaenLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2000-11-26 | BarcelonavOsasunaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2000-11-26 | SantandervEspanolLa Liga · Spain | 1–2 | La Liga · Spain |
| 2000-11-25 | SwindonvStokeLeague One · England | 0–3 | League One · England |
| 2000-11-25 | ClydevAlloaChampionship · Scotland | 0–0 | Championship · Scotland |
| 2000-11-25 | ColchestervWycombeLeague One · England | 0–0 | League One · England |
| 2000-11-25 | Leyton OrientvMacclesfieldLeague Two · England | 2–1 | League Two · England |
| 2000-11-25 | AyrvRaith RvsChampionship · Scotland | 4–2 | Championship · Scotland |
| 2000-11-25 | Nott'm ForestvTranmereChampionship · England | 3–1 | Championship · England |
| 2000-11-25 | QPRvWolvesChampionship · England | 2–2 | Championship · England |
| 2000-11-25 | StrasbourgvLyonLigue 1 · France | 0–3 | Ligue 1 · France |
| 2000-11-25 | Ross CountyvLivingstonChampionship · Scotland | 0–2 | Championship · Scotland |
| 2000-11-25 | MortonvInverness CChampionship · Scotland | 2–0 | Championship · Scotland |
| 2000-11-25 | AtalantavLecceSerie A · Italy | 1–0 | Serie A · Italy |
| 2000-11-25 | Port ValevLutonLeague One · England | 3–0 | League One · England |
| 2000-11-25 | IstanbulsporvBesiktasSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2000-11-25 | Lensv MonacoLigue 1 · France | 4–3 | Ligue 1 · France |
| 2000-11-25 | MechelenvCharleroiPro League · Belgium | 4–3 | Pro League · Belgium |
| 2000-11-25 | Dundee UnitedvDunfermlinePremiership · Scotland | 3–2 | Premiership · Scotland |
| 2000-11-25 | SouthamptonvWest HamPremier League · England | 2–3 | Premier League · England |
| 2000-11-25 | BerwickvForfarLeague One · Scotland | 1–1 | League One · Scotland |
| 2000-11-25 | EvertonvChelseaPremier League · England | 2–1 | Premier League · England |
| 2000-11-25 | East FifevDumbartonLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2000-11-25 | ArbroathvStirlingLeague One · Scotland | 3–2 | League One · Scotland |
| 2000-11-25 | Crystal PalacevStockportChampionship · England | 2–2 | Championship · England |
| 2000-11-25 | TottenhamvLeicesterPremier League · England | 3–0 | Premier League · England |
| 2000-11-25 | CharltonvSunderlandPremier League · England | 0–1 | Premier League · England |
| 2000-11-25 |  Ethiopiav DjiboutiCECAFA Cup | 4–2 | CECAFA Cup |
| 2000-11-25 | LokerenvGentPro League · Belgium | 1–1 | Pro League · Belgium |
| 2000-11-25 | RennesvAuxerreLigue 1 · France | 0–1 | Ligue 1 · France |
| 2000-11-25 | St TruidenvWesterloPro League · Belgium | 1–2 | Pro League · Belgium |
| 2000-11-25 | BarnsleyvPortsmouthChampionship · England | 1–0 | Championship · England |