| 2022-04-18 | Kings LynnvGrimsbyNational League · England | 0–1 | National League · England |
| 2022-04-18 | Bristol CityvSheffield UnitedChampionship · England | 1–1 | Championship · England |
| 2022-04-18 | HaugesundvStromsgodsetEliteserien · Norway | 0–1 | Eliteserien · Norway |
| 2022-04-18 | HIFKvLahtiVeikkausliiga · Finland | 0–3 | Veikkausliiga · Finland |
| 2022-04-18 | NapolivRomaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-04-18 | LincolnvCheltenhamLeague One · England | 3–0 | League One · England |
| 2022-04-18 | LegiavPiast GliwiceEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-04-18 | LuzernvSt. GallenSuper League · Switzerland | 3–2 | Super League · Switzerland |
| 2022-04-18 | WeymouthvYeovilNational League · England | 0–0 | National League · England |
| 2022-04-18 | TernanavFrosinoneSerie B · Italy | 4–4 | Serie B · Italy |
| 2022-04-18 | VicenzavPerugiaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-04-18 | BarnsleyvPeterboroChampionship · England | 0–2 | Championship · England |
| 2022-04-18 | TranmerevExeterLeague Two · England | 2–0 | League Two · England |
| 2022-04-18 | SuttonvNewport CountyLeague Two · England | 1–0 | League Two · England |
| 2022-04-18 | BarnetvSouthendNational League · England | 1–3 | National League · England |
| 2022-04-18 | UC DublinvSt. PatricksPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2022-04-18 | TorquayvEastleighNational League · England | 0–0 | National League · England |
| 2022-04-18 | ReadingvSwanseaChampionship · England | 4–4 | Championship · England |
| 2022-04-18 | Gornik Z.vLechia GdanskEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2022-04-18 | Slask WroclawvWislaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-04-17 | ViborgvOdenseSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2022-04-17 | BurgosvIbizaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-04-17 | SiriusvHelsingborgAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2022-04-17 | Werder BremenvNurnberg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-17 | GranadavLevanteLa Liga · Spain | 1–4 | La Liga · Spain |
| 2022-04-17 | LamiavIonikosSuper League · Greece | 0–1 | Super League · Greece |
| 2022-04-17 | DC UnitedvAustin FCMLS · United States | 2–3 | MLS · United States |
| 2022-04-17 | Avispa FukuokavCerezo OsakaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-04-17 | SochivLokomotiv MoscowPremier League · Russia | 2–2 | Premier League · Russia |
| 2022-04-17 | Wolfsberger ACvA. KlagenfurtBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2022-04-17 | NicevLorientLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-17 | Cruz AzulvGuadalajara ChivasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-17 | HeidenheimvErzgebirge Aue2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-04-17 | CearavBotafogo RJSerie A · Brazil | 1–3 | Serie A · Brazil |
| 2022-04-17 | Los Angeles FCvSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2022-04-17 | Godoy CruzvVelez SarsfieldCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-17 | DarmstadtvSchalke 042. Bundesliga · Germany | 2–5 | 2. Bundesliga · Germany |
| 2022-04-17 | AtromitosvOFI CreteSuper League · Greece | 1–1 | Super League · Greece |
| 2022-04-17 | Chicago FirevLos Angeles GalaxyMLS · United States | 0–0 | MLS · United States |
| 2022-04-17 | Pari NNvKhimkiPremier League · Russia | 0–0 | Premier League · Russia |
| 2022-04-17 | TroyesvStrasbourgLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-04-17 | IwatavSanfrecce HiroshimaJ1 League · Japan | 2–2 | J1 League · Japan |
| 2022-04-17 | Paris SGvMarseilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-17 | Seattle SoundersvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2022-04-17 | ArisvPAOKSuper League · Greece | 1–0 | Super League · Greece |
| 2022-04-17 | LyonvBordeauxLigue 1 · France | 6–1 | Ligue 1 · France |
| 2022-04-17 | Athletico-PRvAtletico-MGSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-04-17 | PonferradinavLugoLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2022-04-17 | West HamvBurnleyPremier League · England | 1–1 | Premier League · England |
| 2022-04-17 | IngolstadtvPaderborn2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |