| 2021-05-01 | RotherhamvBlackburnChampionship · England | 1–1 | Championship · England |
| 2021-05-01 | BesiktasvHataysporSüper Lig · Turkey | 7–0 | Süper Lig · Turkey |
| 2021-05-01 | WealdstonevYeovilNational League · England | 0–2 | National League · England |
| 2021-05-01 | UtrechtvWillem IIEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-05-01 | Forest GreenvTranmereLeague Two · England | 2–1 | League Two · England |
| 2021-05-01 | Pogon SzczecinvWarta PoznanEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-05-01 | GironavTenerifeLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-01 | AmiensvGuingampLigue 2 · France | 0–3 | Ligue 2 · France |
| 2021-05-01 | Real Salt LakevSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2021-05-01 | BrentfordvWatfordChampionship · England | 2–0 | Championship · England |
| 2021-05-01 | WaalwijkvAZ AlkmaarEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-05-01 | MilanvBeneventoSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-05-01 | AFC WimbledonvPortsmouthLeague One · England | 1–3 | League One · England |
| 2021-05-01 | HullvWiganLeague One · England | 3–1 | League One · England |
| 2021-05-01 | Newport CountyvCheltenhamLeague Two · England | 1–0 | League Two · England |
| 2021-05-01 | ElchevAth MadridLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-05-01 | VitessevZwolleEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-05-01 | CF MontrealvColumbus CrewMLS · United States | 0–0 | MLS · United States |
| 2021-05-01 | UTA AradvChindia TargovisteSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-05-01 | AccringtonvCharltonLeague One · England | 1–1 | League One · England |
| 2021-05-01 | Dundee UnitedvRoss CountyPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2021-05-01 | CremonesevRegginaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-05-01 | BoltonvExeterLeague Two · England | 1–2 | League Two · England |
| 2021-05-01 | Colon Santa FEvArsenal SarandiCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-01 | NecaxavAtlasLiga MX · Mexico | 1–5 | Liga MX · Mexico |
| 2021-05-01 | NorthamptonvBlackpoolLeague One · England | 0–3 | League One · England |
| 2021-05-01 | Fleetwood TownvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2021-05-01 | FC TokyovYokohama F. MarinosJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-05-01 | SwindonvIpswichLeague One · England | 1–2 | League One · England |
| 2021-05-01 | EvertonvAston VillaPremier League · England | 1–2 | Premier League · England |
| 2021-05-01 | CSKA MoscowvUfaPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-05-01 | GrimsbyvPort ValeLeague Two · England | 1–0 | League Two · England |
| 2021-05-01 | BarnetvDag and RedNational League · England | 0–2 | National League · England |
| 2021-05-01 | Santa ClaravBoavistaPrimeira Liga · Portugal | 3–3 | Primeira Liga · Portugal |
| 2021-05-01 | EibarvAlavesLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-05-01 | SwanseavDerbyChampionship · England | 2–1 | Championship · England |
| 2021-05-01 | DunkerquevSochauxLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-05-01 | StokevQPRChampionship · England | 0–2 | Championship · England |
| 2021-05-01 | TorquayvEastleighNational League · England | 3–1 | National League · England |
| 2021-05-01 | MansfieldvOldhamLeague Two · England | 4–1 | League Two · England |
| 2021-05-01 | For SittardvTwenteEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-05-01 | BaselvSt. GallenSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2021-05-01 | NancyvValenciennesLigue 2 · France | 1–3 | Ligue 2 · France |
| 2021-05-01 | LillevNiceLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-05-01 | CrotonevInterSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-05-01 | Guadalajara ChivasvTigres UANLLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-05-01 | BurtonvGillinghamLeague One · England | 1–1 | League One · England |
| 2021-05-01 | HibernianvSt JohnstonePremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-05-01 | RochdalevDoncasterLeague One · England | 1–2 | League One · England |
| 2021-05-01 | Le HavrevChamblyLigue 2 · France | 2–4 | Ligue 2 · France |