| 2022-04-18 | PisavComoSerie B · Italy | 3–1 | Serie B · Italy |
| 2022-04-18 | BanfieldvRiver PlateCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-18 | CittadellavAlessandriaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-04-18 | AFC WimbledonvWycombeLeague One · England | 1–1 | League One · England |
| 2022-04-18 | MorecambevPortsmouthLeague One · England | 1–1 | League One · England |
| 2022-04-18 | PlymouthvSunderlandLeague One · England | 0–0 | League One · England |
| 2022-04-18 | MoldevLillestromEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2022-04-18 | VPSvHJKVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2022-04-18 | HalifaxvChesterfieldNational League · England | 2–0 | National League · England |
| 2022-04-18 | SwindonvLeyton OrientLeague Two · England | 1–2 | League Two · England |
| 2022-04-18 | AtalantavVeronaSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-04-18 | PordenonevBeneventoSerie B · Italy | 1–4 | Serie B · Italy |
| 2022-04-18 | WealdstonevBoreham WoodNational League · England | 2–0 | National League · England |
| 2022-04-18 | BromleyvMaidenheadNational League · England | 0–0 | National League · England |
| 2022-04-18 | VejlevNordsjaellandSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2022-04-18 | MonzavBresciaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-04-18 | CoventryvBournemouthChampionship · England | 0–3 | Championship · England |
| 2022-04-18 | WrexhamvAltrinchamNational League · England | 4–0 | National League · England |
| 2022-04-18 | CracoviavZaglebieEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-04-18 | RochdalevHartlepoolLeague Two · England | 2–1 | League Two · England |
| 2022-04-18 | ScunthorpevStevenageLeague Two · England | 1–1 | League Two · England |
| 2022-04-18 | Dover AthleticvWokingNational League · England | 1–4 | National League · England |
| 2022-04-18 | ColchestervBradfordLeague Two · England | 3–0 | League Two · England |
| 2022-04-18 | BoltonvAccringtonLeague One · England | 3–1 | League One · England |
| 2022-04-18 | Bodo/GlimtvValerengaEliteserien · Norway | 5–1 | Eliteserien · Norway |
| 2022-04-18 | FC CopenhagenvBrondbySuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2022-04-18 | RegginavLecceSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-18 | GalatasarayvYeni MalatyasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2022-04-18 | GironavSociedad BLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2022-04-18 | CardiffvLutonChampionship · England | 0–1 | Championship · England |
| 2022-04-18 | SalfordvBarrowLeague Two · England | 2–2 | League Two · England |
| 2022-04-18 | ParmavAscoliSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-04-18 | BlackpoolvBirminghamChampionship · England | 6–1 | Championship · England |
| 2022-04-18 | StockportvSolihullNational League · England | 1–0 | National League · England |
| 2022-04-18 | Port ValevBristol RvsLeague Two · England | 1–3 | League Two · England |
| 2022-04-18 | MidtjyllandvAalborgSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2022-04-18 | GianninavAEKSuper League · Greece | 2–3 | Super League · Greece |
| 2022-04-18 | Crawley TownvWalsallLeague Two · England | 1–0 | League Two · England |
| 2022-04-18 | OddvVikingEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2022-04-18 | SionvBaselSuper League · Switzerland | 0–0 | Super League · Switzerland |
| 2022-04-18 | CarlislevMansfieldLeague Two · England | 1–0 | League Two · England |
| 2022-04-18 | SpalvCrotoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-04-18 | LausannevLuganoSuper League · Switzerland | 4–1 | Super League · Switzerland |
| 2022-04-18 | ShelbournevBohemiansPremier Division · Ireland | 1–4 | Premier Division · Ireland |
| 2022-04-18 | GillinghamvFleetwood TownLeague One · England | 0–0 | League One · England |
| 2022-04-18 | DroghedavDerry CityPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2022-04-18 | NorthamptonvHarrogateLeague Two · England | 3–0 | League Two · England |
| 2022-04-18 | BarcelonavCadizLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-04-18 | AalesundvTromsoEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2022-04-18 | Nott'm ForestvWest BromChampionship · England | 4–0 | Championship · England |