| 2021-05-02 | New England RevolutionvAtlanta UtdMLS · United States | 2–1 | MLS · United States |
| 2021-05-02 | VillarrealvGetafeLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-05-02 | MidtjyllandvNordsjaellandSuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2021-05-02 | Viitorul ConstantavDin. BucurestiSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-05-02 | KhimkivUralPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-05-02 | San LorenzovGodoy CruzCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | HalmstadvGoteborgAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-02 | Henan Songshan LongmenvShandong TaishanSuper League · China | 1–1 | Super League · China |
| 2021-05-02 | CastellonvLogronesLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-05-02 | Nashville SCvInter MiamiMLS · United States | 0–0 | MLS · United States |
| 2021-05-02 | Cruz AzulvClub TijuanaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-05-02 | DenizlisporvRizesporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-05-02 | NapolivCagliariSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-02 | SonderjyskevOdenseSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-05-02 | GranadavCadizLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-05-02 | San Jose EarthquakesvDC UnitedMLS · United States | 4–1 | MLS · United States |
| 2021-05-02 | FuenlabradavCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-05-02 | Shonan BellmarevHokkaido Consadole SapporoJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-05-02 | EspanolvMalagaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-05-02 | NewcastlevArsenalPremier League · England | 0–2 | Premier League · England |
| 2021-05-02 | Central CordobavRacing ClubCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | AntalyasporvGoztepSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-05-02 | Randers FCvBrondbySuperliga · Denmark | 4–2 | Superliga · Denmark |
| 2021-05-02 | AjaxvFC EmmenEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2021-05-02 | MonterreyvMazatlan FCLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-05-02 | ZurichvLuganoSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2021-05-02 | Las PalmasvPonferradinaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-05-02 | FK RostovvTambovPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-05-02 | BolognavFiorentinaSerie A · Italy | 3–3 | Serie A · Italy |
| 2021-05-02 | Orlando CityvFC CincinnatiMLS · United States | 3–0 | MLS · United States |
| 2021-05-02 | KuPSvHJKVeikkausliiga · Finland | 0–0 | Veikkausliiga · Finland |
| 2021-05-02 | Boca JuniorsvLanusCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | ZenitvLokomotiv MoscowPremier League · Russia | 6–1 | Premier League · Russia |
| 2021-05-02 | Den HaagvFeyenoordEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-05-02 | Guangzhou FCvShenzhenSuper League · China | 2–0 | Super League · China |
| 2021-05-02 | FC VoluntarivFC HermannstadtSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-05-02 | ServettevYoung BoysSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-05-02 | SassuolovAtalantaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-02 | OstersundsvVarbergAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-05-02 | GenclerbirligivGalatasaraySüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-05-02 | BordeauxvRennesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-05-02 | BanfieldvRiver PlateCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | ValenciavBarcelonaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2021-05-02 | Cerezo OsakavGamba OsakaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-05-02 | RangersvCelticPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2021-05-02 | OrebrovNorrkopingAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2021-05-02 | PSV EindhovenvHeerenveenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-05-01 | AltrinchamvNotts CountyNational League · England | 1–1 | National League · England |
| 2021-05-01 | SuttonvAldershotNational League · England | 3–1 | National League · England |
| 2021-05-01 | NiortvRodezLigue 2 · France | 1–1 | Ligue 2 · France |