| 2016-04-17 | NorrkopingvAIKAllsvenskan · Sweden | 4–1 | Allsvenskan · Sweden |
| 2016-04-17 | KubanvFK RostovPremier League · Russia | 0–1 | Premier League · Russia |
| 2016-04-17 | IraklisvPanetolikosSuper League · Greece | 0–0 | Super League · Greece |
| 2016-04-17 | Seattle SoundersvPhiladelphia UnionMLS · United States | 2–1 | MLS · United States |
| 2016-04-17 | AjaxvUtrechtEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2016-04-17 | LevadeiakosvAEKSuper League · Greece | 3–0 | Super League · Greece |
| 2016-04-17 | Racing ClubvArgentinos JrsLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2016-04-17 | XanthivGianninaSuper League · Greece | 0–1 | Super League · Greece |
| 2016-04-17 | AtalantavRomaSerie A · Italy | 3–3 | Serie A · Italy |
| 2016-04-17 | BournemouthvLiverpoolPremier League · England | 1–2 | Premier League · England |
| 2016-04-17 | FC CopenhagenvBrondbySuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2016-04-17 | PanathinaikosvPanthrakikosSuper League · Greece | 6–1 | Super League · Greece |
| 2016-04-17 | Sarpsborg 08vStabaekEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2016-04-17 | Chongqing Liangjiang AthleticvChangchun YataiSuper League · China | 1–1 | Super League · China |
| 2016-04-17 | San Martin S.J.vEstudiantes L.P.Liga Profesional · Argentina | 0–2 | Liga Profesional · Argentina |
| 2016-04-17 | GimnasticvOviedoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-04-17 | Uniao MadeiravPacos FerreiraPrimeira Liga · Portugal | 3–4 | Primeira Liga · Portugal |
| 2016-04-17 | Columbus CrewvNew York CityMLS · United States | 3–2 | MLS · United States |
| 2016-04-17 | LaziovEmpoliSerie A · Italy | 2–0 | Serie A · Italy |
| 2016-04-17 | KasimpasavKayserisporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2016-04-17 | Real Salt LakevVancouver WhitecapsMLS · United States | 1–0 | MLS · United States |
| 2016-04-17 | WislavGornik Z.Ekstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2016-04-17 | OlympiakosvKallonisSuper League · Greece | 5–0 | Super League · Greece |
| 2016-04-17 | VeronavFrosinoneSerie A · Italy | 1–2 | Serie A · Italy |
| 2016-04-17 | Din. BucurestivTargu MuresSuperliga · Romania | 1–0 | Superliga · Romania |
| 2016-04-17 |  MonacovMarseilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2016-04-17 | BuyuksehyrvGaziantepsporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2016-04-17 | FenerbahcevMersin Idman YurduSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2016-04-17 | Greuther FurthvFortuna Dusseldorf2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2016-04-17 | FiorentinavSassuoloSerie A · Italy | 3–1 | Serie A · Italy |
| 2016-04-17 | ArsenalvCrystal PalacePremier League · England | 1–1 | Premier League · England |
| 2016-04-17 | Portland TimbersvSan Jose EarthquakesMLS · United States | 3–1 | MLS · United States |
| 2016-04-17 | Colorado RapidsvNew York Red BullsMLS · United States | 2–1 | MLS · United States |
| 2016-04-17 | Asteras TripolisvVeriaSuper League · Greece | 2–1 | Super League · Greece |
| 2016-04-17 | PonferradinavAlmeriaLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2016-04-17 | OdensevViborgSuperliga · Denmark | 5–1 | Superliga · Denmark |
| 2016-04-17 | OddvStartEliteserien · Norway | 3–0 | Eliteserien · Norway |
| 2016-04-17 | MainzvFC KolnBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2016-04-17 | Dynamo MoscowvKrylya SovetovPremier League · Russia | 0–1 | Premier League · Russia |
| 2016-04-17 | PlataniasvPAOKSuper League · Greece | 0–0 | Super League · Greece |
| 2016-04-17 | Young BoysvVaduzSuper League · Switzerland | 5–4 | Super League · Switzerland |
| 2016-04-17 | MonarcasvPachucaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2016-04-17 | Bodo/GlimtvMoldeEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2016-04-17 | Hangzhou GreentownvBeijing GuoanSuper League · China | 0–3 | Super League · China |
| 2016-04-17 | JagielloniavLecznaEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2016-04-17 | FC VoluntarivConcordiaSuperliga · Romania | 1–2 | Superliga · Romania |
| 2016-04-17 | St. GallenvBaselSuper League · Switzerland | 0–7 | Super League · Switzerland |
| 2016-04-17 | PortovNacionalPrimeira Liga · Portugal | 4–0 | Primeira Liga · Portugal |
| 2016-04-17 | BielefeldvKaiserslautern2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2016-04-17 | PS KemivMariehamnVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |