| 2022-04-20 | AIKvVarbergAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2022-04-20 | Lech PoznanvLecznaEkstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2022-04-20 | BordeauxvSt EtienneLigue 1 · France | 2–2 | Ligue 1 · France |
| 2022-04-20 | CeltavGetafeLa Liga · Spain | 0–2 | La Liga · Spain |
| 2022-04-20 | Ath MadridvGranadaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-04-20 | Pogon SzczecinvRakowEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2022-04-19 | VitessevSparta RotterdamEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-04-19 | FulhamvPrestonChampionship · England | 3–0 | Championship · England |
| 2022-04-19 | CambridgevCharltonLeague One · England | 0–2 | League One · England |
| 2022-04-19 | AuxerrevDijonLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-19 | Randers FCvSilkeborgSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2022-04-19 | RodezvNancyLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-19 | HuracanvColon Santa FECopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-19 | AjacciovDunkerqueLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-19 | Arsenal SarandivBarracas CentralCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-19 | Sheffield WedsvCreweLeague One · England | 1–0 | League One · England |
| 2022-04-19 | GrenoblevValenciennesLigue 2 · France | 3–0 | Ligue 2 · France |
| 2022-04-19 | Union de Santa FevSan LorenzoCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-19 | BetisvElcheLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-04-19 | MallorcavAlavesLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-04-19 | OxfordvMilton Keynes DonsLeague One · England | 1–0 | League One · England |
| 2022-04-19 | GuingampvPau FCLigue 2 · France | 3–0 | Ligue 2 · France |
| 2022-04-19 | Paris FCvCaenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-04-19 | VillarrealvValenciaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-04-19 | Queen of SthvInverness CChampionship · Scotland | 2–1 | Championship · Scotland |
| 2022-04-19 | NiortvBastiaLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-19 | Estudiantes L.P.vTigreCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-19 | LiverpoolvMan UnitedPremier League · England | 4–0 | Premier League · England |
| 2022-04-19 | IpswichvWiganLeague One · England | 2–2 | League One · England |
| 2022-04-19 | Quevilly RouenvNimesLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-04-19 | BurtonvRotherhamLeague One · England | 2–0 | League One · England |
| 2022-04-19 | AmiensvLe HavreLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-04-19 | SochauxvToulouseLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-18 | CremonesevCosenzaSerie B · Italy | 3–1 | Serie B · Italy |
| 2022-04-18 | ShrewsburyvDoncasterLeague One · England | 3–3 | League One · England |
| 2022-04-18 | BlackburnvStokeChampionship · England | 0–1 | Championship · England |
| 2022-04-18 | Forest GreenvOldhamLeague Two · England | 2–0 | League Two · England |
| 2022-04-18 | FC Rapid BucurestivGaz Metan MediasSuperliga · Romania | 8–0 | Superliga · Romania |
| 2022-04-18 | Shamrock RoversvDundalkPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2022-04-18 | Ham-KamvSandefjordEliteserien · Norway | 3–0 | Eliteserien · Norway |
| 2022-04-18 | QPRvDerbyChampionship · England | 1–0 | Championship · England |
| 2022-04-18 | MariehamnvHonkaVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2022-04-18 | EstorilvSp BragaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2022-04-18 | Finn HarpsvSligo RoversPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2022-04-18 | MillwallvHullChampionship · England | 2–1 | Championship · England |
| 2022-04-18 | SonderjyskevAarhusSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2022-04-18 | AldershotvDag and RedNational League · England | 0–2 | National League · England |
| 2022-04-18 | JervvKristiansundEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2022-04-18 | MiddlesbroughvHuddersfieldChampionship · England | 0–2 | Championship · England |
| 2022-04-18 | Sarpsborg 08vRosenborgEliteserien · Norway | 1–1 | Eliteserien · Norway |