| 2021-05-03 | Shamrock RoversvWaterfordPremier Division · Ireland | 3–0 | Premier Division · Ireland |
| 2021-05-03 | MainzvHerthaBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-05-03 | CracoviavGornik Z.Ekstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-05-03 | SevillavAth BilbaoLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-05-03 | Santos LagunavPueblaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-05-03 | StockportvWealdstoneNational League · England | 4–0 | National League · England |
| 2021-05-03 | SJKvKTPVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2021-05-03 | MjallbyvDegerforsAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-05-03 | Sarmiento JuninvGimnasia L.P.Copa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-03 | DroghedavBohemiansPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-05-03 | West BromvWolvesPremier League · England | 1–1 | Premier League · England |
| 2021-05-03 | Qingdao FCvGuangzhou CitySuper League · China | 0–1 | Super League · China |
| 2021-05-03 | Chongqing Liangjiang AthleticvCangzhouSuper League · China | 2–2 | Super League · China |
| 2021-05-03 | BuyuksehyrvAnkaragucuSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-05-03 | Vancouver WhitecapsvColorado RapidsMLS · United States | 0–1 | MLS · United States |
| 2021-05-03 | HIFKvHakaVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-05-03 | LahtivInter TurkuVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2021-05-03 | AC OuluvIlvesVeikkausliiga · Finland | 0–2 | Veikkausliiga · Finland |
| 2021-05-03 | UNAM PumasvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-05-03 | Derry CityvFinn HarpsPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2021-05-03 | DjurgardenvMalmo FFAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2021-05-03 | AlbacetevAlcorconLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-05-03 | Boreham WoodvKings LynnNational League · England | 5–1 | National League · England |
| 2021-05-03 | TorinovParmaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-05-02 | LeganesvSp GijonLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-05-02 | Talleres CordobavHuracanCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | Oita TrinitavShimizu S-PulseJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-05-02 | SionvLausanneSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-05-02 | MontpelliervSt EtienneLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-05-02 | Philadelphia UnionvNew York CityMLS · United States | 0–2 | MLS · United States |
| 2021-05-02 | AIKvElfsborgAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-05-02 | UdinesevJuventusSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-05-02 | BrestvNantesLigue 1 · France | 1–4 | Ligue 1 · France |
| 2021-05-02 | AldosivivArgentinos JrsCopa De La Liga Profesional · Argentina | 1–3 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | LaziovGenoaSerie A · Italy | 4–3 | Serie A · Italy |
| 2021-05-02 | TottenhamvSheffield UnitedPremier League · England | 4–0 | Premier League · England |
| 2021-05-02 | SampdoriavRomaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-05-02 | LorientvAngersLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-05-02 | Defensa y JusticiavUnion de Santa FeCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | DijonvMetzLigue 1 · France | 1–5 | Ligue 1 · France |
| 2021-05-02 | Academica ClincenivUniv. CraiovaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-05-02 | NimesvReimsLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-05-02 | ValladolidvBetisLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-05-02 | GroningenvSparta RotterdamEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-05-02 | KonyasporvKaragumrukSüper Lig · Turkey | 5–1 | Süper Lig · Turkey |
| 2021-05-02 | AstravPoli IasiSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-05-02 | Minnesota UnitedvAustin FCMLS · United States | 0–1 | MLS · United States |
| 2021-05-02 | IndependientevAtl. TucumanCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-02 | FC DallasvPortland TimbersMLS · United States | 4–1 | MLS · United States |
| 2021-05-02 |  MonacovLyonLigue 1 · France | 2–3 | Ligue 1 · France |