| 2022-04-22 | HakavHIFKVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2022-04-22 | RizesporvFenerbahceSüper Lig · Turkey | 0–6 | Süper Lig · Turkey |
| 2022-04-22 | BohemiansvShamrock RoversPremier Division · Ireland | 1–3 | Premier Division · Ireland |
| 2022-04-21 | VarnamovMalmo FFAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2022-04-21 | Club AmericavClub LeonLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-04-21 | Sarmiento JuninvDefensa y JusticiaCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-21 | SociedadvBarcelonaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-04-21 | MonterreyvAtlasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2022-04-21 | DegerforsvHammarbyAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2022-04-21 | Boca JuniorsvGodoy CruzCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-21 | Atl. TucumanvArgentinos JrsCopa De La Liga Profesional · Argentina | 2–4 | Copa De La Liga Profesional · Argentina |
| 2022-04-21 | LevantevSevillaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2022-04-21 | EspanolvVallecanoLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-04-21 | HelsingborgvElfsborgAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2022-04-21 | CadizvAth BilbaoLa Liga · Spain | 2–3 | La Liga · Spain |
| 2022-04-21 | Atl. San LuisvUNAM PumasLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-04-21 | BurnleyvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2022-04-20 | UdinesevSalernitanaSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-04-20 | ReimsvLilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-20 | Velez SarsfieldvCentral CordobaCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-20 | TroyesvClermontLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-04-20 | MjallbyvSiriusAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2022-04-20 | TolucavJuarezLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-20 | GoteborgvDjurgardenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2022-04-20 | EvertonvLeicesterPremier League · England | 1–1 | Premier League · England |
| 2022-04-20 | LorientvMetzLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-04-20 | LensvMontpellierLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-04-20 | PatronatovRacing ClubCopa De La Liga Profesional · Argentina | 2–3 | Copa De La Liga Profesional · Argentina |
| 2022-04-20 | ChelseavArsenalPremier League · England | 2–4 | Premier League · England |
| 2022-04-20 | StrasbourgvRennesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-20 | BrestvLyonLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-04-20 | Flamengo RJvPalmeirasSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2022-04-20 | AngersvParis SGLigue 1 · France | 0–3 | Ligue 1 · France |
| 2022-04-20 |  MonacovNiceLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-04-20 | Mazatlan FCvSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-04-20 | Guadalajara ChivasvClub TijuanaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-04-20 | Man CityvBrightonPremier League · England | 3–0 | Premier League · England |
| 2022-04-20 | NewcastlevCrystal PalacePremier League · England | 1–0 | Premier League · England |
| 2022-04-20 | NecaxavTigres UANLLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-04-20 | NorrkopingvHackenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2022-04-20 | PlatensevGimnasia L.P.Copa De La Liga Profesional · Argentina | 0–3 | Copa De La Liga Profesional · Argentina |
| 2022-04-20 | IndependientevAldosiviCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-20 | PachucavPueblaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-04-20 | MarseillevNantesLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-04-20 | Talleres CordobavRiver PlateCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-20 | FC TokyovNagoya GrampusJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-04-20 | Newells Old BoysvBanfieldCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-20 | SundsvallvKalmarAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2022-04-20 | LanusvRosario CentralCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-20 | OsasunavReal MadridLa Liga · Spain | 1–3 | La Liga · Spain |