| 2021-05-04 | CowdenbeathvAlbion RvsLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-05-04 | RegginavAscoliSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-05-04 | ChievovCremoneseSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-05-04 | DumbartonvPeterheadLeague One · Scotland | 3–2 | League One · Scotland |
| 2021-05-04 | StranraervEdinburgh CityLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2021-05-04 | EmpolivCosenzaSerie B · Italy | 4–0 | Serie B · Italy |
| 2021-05-04 | BlackpoolvDoncasterLeague One · England | 2–0 | League One · England |
| 2021-05-04 | Kawasaki FrontalevNagoya GrampusJ1 League · Japan | 3–2 | J1 League · Japan |
| 2021-05-04 | BrechinvStenhousemuirLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-05-04 | PordenonevSalernitanaSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-05-04 | Le HavrevToulouseLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-05-04 | PisavVeneziaSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-05-04 | LutonvRotherhamChampionship · England | 0–0 | Championship · England |
| 2021-05-04 | Notts CountyvSuttonNational League · England | 3–2 | National League · England |
| 2021-05-04 | MonzavLecceSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-05-04 | SpalvFrosinoneSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-05-04 | ElginvQueens ParkLeague Two · Scotland | 3–2 | League Two · Scotland |
| 2021-05-04 | CittadellavVirtus EntellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-05-04 | ForfarvEast FifeLeague One · Scotland | 2–3 | League One · Scotland |
| 2021-05-04 | Holstein KielvSandhausen2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-05-04 | Airdrie UtdvFalkirkLeague One · Scotland | 2–0 | League One · Scotland |
| 2021-05-04 | Beijing GuoanvDalian ProSuper League · China | 2–0 | Super League · China |
| 2021-05-04 | MontrosevPartickLeague One · Scotland | 3–2 | League One · Scotland |
| 2021-05-04 | Chindia TargovistevGaz Metan MediasSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-05-04 | VicenzavBresciaSerie B · Italy | 0–3 | Serie B · Italy |
| 2021-05-03 | Fortuna DusseldorfvKarlsruhe2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-05-03 | Estudiantes L.P.vPlatenseCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-03 | Rosario CentralvNewells Old BoysCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-03 | KasimpasavAlanyasporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-05-03 | HonkavMariehamnVeikkausliiga · Finland | 0–2 | Veikkausliiga · Finland |
| 2021-05-03 | Piast GliwicevPodbeskidzieEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-05-03 | FCSBvCFR ClujSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-05-03 | SabadellvVallecanoLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-05-03 | MaidenheadvWrexhamNational League · England | 2–2 | National League · England |
| 2021-05-03 | Arsenal TulavSpartak MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-05-03 | Seattle SoundersvLos Angeles GalaxyMLS · United States | 3–0 | MLS · United States |
| 2021-05-03 | BurnleyvWest HamPremier League · England | 1–2 | Premier League · England |
| 2021-05-03 | BromleyvHartlepoolNational League · England | 1–0 | National League · England |
| 2021-05-03 | LongfordvDundalkPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2021-05-03 | WeymouthvBarnetNational League · England | 0–2 | National League · England |
| 2021-05-03 | FC CopenhagenvAarhusSuperliga · Denmark | 3–2 | Superliga · Denmark |
| 2021-05-03 | GrenoblevClermontLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-05-03 | GaziantepvSivassporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-05-03 | Sligo RoversvSt. PatricksPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-05-03 | FenerbahcevErzurum BBSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-05-03 | ChesterfieldvTorquayNational League · England | 0–2 | National League · England |
| 2021-05-03 | YeovilvHalifaxNational League · England | 0–3 | National League · England |
| 2021-05-03 | Dag and RedvWokingNational League · England | 3–1 | National League · England |
| 2021-05-03 | Yeni MalatyasporvKayserisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-05-03 | SolihullvAltrinchamNational League · England | 4–0 | National League · England |