| 2022-04-23 | WalsallvPort ValeLeague Two · England | 2–0 | League Two · England |
| 2022-04-23 | PeterheadvEast FifeLeague One · Scotland | 1–0 | League One · Scotland |
| 2022-04-23 | CambuurvPSV EindhovenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-04-23 | Young BoysvServetteSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2022-04-23 | MortonvInverness CChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-04-23 | HullvReadingChampionship · England | 3–0 | Championship · England |
| 2022-04-23 | Philadelphia UnionvCF MontrealMLS · United States | 1–1 | MLS · United States |
| 2022-04-23 | Slask WroclawvTermalica B-B.Ekstraklasa · Poland | 0–4 | Ekstraklasa · Poland |
| 2022-04-23 | Kelty HeartsvForfarLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2022-04-23 | FC Rapid BucurestivSepsi Sf. GheorgheSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-04-23 | NorwichvNewcastlePremier League · England | 0–3 | Premier League · England |
| 2022-04-23 | LutonvBlackpoolChampionship · England | 1–1 | Championship · England |
| 2022-04-23 | FC KolnvBielefeldBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-04-23 | Ad. DemirsporvTrabzonsporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2022-04-23 | Fleetwood TownvAFC WimbledonLeague One · England | 1–1 | League One · England |
| 2022-04-23 | WycombevSheffield WedsLeague One · England | 1–0 | League One · England |
| 2022-04-23 | MansfieldvCrawley TownLeague Two · England | 2–0 | League Two · England |
| 2022-04-23 | StevenagevTranmereLeague Two · England | 2–0 | League Two · England |
| 2022-04-23 | Albion RvsvStirlingLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2022-04-23 | KaragumrukvGiresunsporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-04-23 | Piast GliwicevJagielloniaEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2022-04-22 | ValenciennesvAjaccioLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-04-22 | DunkerquevAmiensLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-04-22 | St. PatricksvFinn HarpsPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2022-04-22 | TenerifevHuescaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-04-22 | KarlsruhevIngolstadt2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-22 | DundalkvShelbournePremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2022-04-22 | WolfsburgvMainzBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2022-04-22 | LahtivKuPSVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2022-04-22 | TwentevSparta RotterdamEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2022-04-22 | BastiavParis FCLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-22 | HuddersfieldvBarnsleyChampionship · England | 2–1 | Championship · England |
| 2022-04-22 | Gaz Metan MediasvDin. BucurestiSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-04-22 | Elba IslandvVatican CityFriendly | 4–2 | Friendly |
| 2022-04-22 | QueretarovCruz AzulLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-22 | Academica ClincenivMioveniSuperliga · Romania | 0–2 | Superliga · Romania |
| 2022-04-22 | Fortuna DusseldorfvDresden2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-22 | Derry CityvUC DublinPremier Division · Ireland | 7–1 | Premier Division · Ireland |
| 2022-04-22 | Pau FCvSochauxLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-04-22 | NancyvQuevilly RouenLigue 2 · France | 0–3 | Ligue 2 · France |
| 2022-04-22 | VizelavAroucaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-04-22 | Newport CountyvColchesterLeague Two · England | 1–2 | League Two · England |
| 2022-04-22 | KilmarnockvArbroathChampionship · Scotland | 2–1 | Championship · Scotland |
| 2022-04-22 | NimesvRodezLigue 2 · France | 3–2 | Ligue 2 · France |
| 2022-04-22 | ZaglebievGornik Z.Ekstraklasa · Poland | 2–4 | Ekstraklasa · Poland |
| 2022-04-22 | Radomiak RadomvCracoviaEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-04-22 | SonderjyskevVejleSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2022-04-22 | Le HavrevGrenobleLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-04-22 | DijonvGuingampLigue 2 · France | 3–3 | Ligue 2 · France |
| 2022-04-22 | Edinburgh CityvAnnan AthleticLeague Two · Scotland | 2–1 | League Two · Scotland |