| 2021-05-07 | HannovervDarmstadt2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-05-07 | Holstein KielvSt Pauli2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-05-07 | LensvLilleLigue 1 · France | 0–3 | Ligue 1 · France |
| 2021-05-07 | FrosinonevVicenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-05-07 | AscolivCittadellaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-05-07 | TenerifevAlmeriaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-05-07 | Derry CityvLongfordPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-05-07 | VeneziavPordenoneSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-05-07 | LeccevRegginaSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-05-07 | SJKvHIFKVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2021-05-07 | SochivR. VolgogradPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-05-07 | Gornik Z.vJagielloniaEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2021-05-07 | StuttgartvAugsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-05-07 | DundalkvSligo RoversPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-05-07 | LeicestervNewcastlePremier League · England | 2–4 | Premier League · England |
| 2021-05-07 | ReggianavSpalSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-05-07 | Sparta RotterdamvVitesseEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-05-07 | KTPvHonkaVeikkausliiga · Finland | 1–3 | Veikkausliiga · Finland |
| 2021-05-07 | CosenzavMonzaSerie B · Italy | 0–3 | Serie B · Italy |
| 2021-05-07 | BoavistavTondelaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-05-07 | SalernitanavEmpoliSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-05-07 | SociedadvElcheLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-05-07 | ZaglebievPogon SzczecinEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-05-07 | BresciavPisaSerie B · Italy | 4–3 | Serie B · Italy |
| 2021-05-06 | FarensevGuimaraesPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-05-06 | HerthavFreiburgBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-05-06 | Academica ClincenivCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-05-06 | MoreirensevNacionalPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-05-06 | ClydevEast FifeLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-05-06 | BenficavPortoPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-05-06 | FC ArgesvFC VoluntariSuperliga · Romania | 3–0 | Superliga · Romania |
| 2021-05-06 | FC BotosanivFCSBSuperliga · Romania | 1–3 | Superliga · Romania |
| 2021-05-06 | BelenensesvPortimonensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-05-05 | MaritimovGil VicentePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-05-05 | Stal MielecvRakowEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-05-05 | Rio AvevSp LisbonPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-05-05 | FC HermannstadtvViitorul ConstantaSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-05-05 | PanathinaikosvAsteras TripolisSuper League · Greece | 2–2 | Super League · Greece |
| 2021-05-05 | Sepsi Sf. GheorghevUniv. CraiovaSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-05-05 | ArisvOlympiakosSuper League · Greece | 1–1 | Super League · Greece |
| 2021-05-05 | Sp BragavPacos FerreiraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-05-05 | Shanghai ShenhuavShanghai PortSuper League · China | 1–1 | Super League · China |
| 2021-05-05 | Tianjin Jinmen TigervHebeiSuper League · China | 0–1 | Super League · China |
| 2021-05-05 | AEKvPAOKSuper League · Greece | 1–2 | Super League · Greece |
| 2021-05-05 | Poli IasivDin. BucurestiSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-05-05 | AstravUTA AradSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-05-04 | CharltonvLincolnLeague One · England | 3–1 | League One · England |
| 2021-05-04 | PescaravReggianaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-05-04 | Changchun YataivWuhan FCSuper League · China | 0–0 | Super League · China |
| 2021-05-04 | ShrewsburyvIpswichLeague One · England | 0–0 | League One · England |