| 2022-04-23 | SochivAkhmat GroznyPremier League · Russia | 3–2 | Premier League · Russia |
| 2022-04-23 | LASKvAltachBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2022-04-23 | BournemouthvFulhamChampionship · England | 1–1 | Championship · England |
| 2022-04-23 | Santa ClaravMaritimoPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2022-04-23 | CrewevIpswichLeague One · England | 1–1 | League One · England |
| 2022-04-23 | RB LeipzigvUnion BerlinBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-04-23 | MotherwellvRangersPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2022-04-23 | Dag and RedvKings LynnNational League · England | 1–1 | National League · England |
| 2022-04-23 | AZ AlkmaarvHeerenveenEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-04-23 | FuenlabradavPonferradinaLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2022-04-23 | Athletico-PRvFlamengo RJSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2022-04-23 | UTA AradvChindia TargovisteSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-04-23 | LyonvMontpellierLigue 1 · France | 5–2 | Ligue 1 · France |
| 2022-04-23 | JuarezvMazatlan FCLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2022-04-23 | CheltenhamvBoltonLeague One · England | 1–2 | League One · England |
| 2022-04-23 | DerbyvBristol CityChampionship · England | 1–3 | Championship · England |
| 2022-04-23 | WokingvWrexhamNational League · England | 2–1 | National League · England |
| 2022-04-23 | AlderneyvGuernseyMuratti Vase | 0–2 | Muratti Vase |
| 2022-04-23 | FalkirkvAlloaLeague One · Scotland | 1–2 | League One · Scotland |
| 2022-04-23 | West BromvCoventryChampionship · England | 0–0 | Championship · England |
| 2022-04-23 | Sligo RoversvDroghedaPremier Division · Ireland | 3–2 | Premier Division · Ireland |
| 2022-04-23 | GaziantepvGoztepSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-04-23 | OddvAalesundEliteserien · Norway | 2–3 | Eliteserien · Norway |
| 2022-04-23 | FC DallasvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2022-04-23 | EastleighvBarnetNational League · England | 2–3 | National League · England |
| 2022-04-23 | St PaulivDarmstadt2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-04-23 | Lechia GdanskvWarta PoznanEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2022-04-23 | OldhamvSalfordLeague Two · England | 1–2 | League Two · England |
| 2022-04-23 | Bristol RvsvForest GreenLeague Two · England | 0–0 | League Two · England |
| 2022-04-23 | TorinovSpeziaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-04-23 | DundeevSt JohnstonePremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-04-23 | HartlepoolvSwindonLeague Two · England | 0–3 | League Two · England |
| 2022-04-23 | LeicestervAston VillaPremier League · England | 0–0 | Premier League · England |
| 2022-04-23 | StokevQPRChampionship · England | 1–0 | Championship · England |
| 2022-04-23 | Sociedad BvAmorebietaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-04-23 | BarrowvSuttonLeague Two · England | 1–0 | League Two · England |
| 2022-04-23 | BenficavFamalicaoPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2022-04-23 | PortsmouthvGillinghamLeague One · England | 3–1 | League One · England |
| 2022-04-23 | DoncastervBurtonLeague One · England | 2–0 | League One · England |
| 2022-04-23 | Minnesota UnitedvChicago FireMLS · United States | 3–0 | MLS · United States |
| 2022-04-23 | PachucavMonterreyLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2022-04-23 | VeronavSampdoriaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-04-23 | Lokomotiv MoscowvPari NNPremier League · Russia | 2–1 | Premier League · Russia |
| 2022-04-23 | AberdeenvLivingstonPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2022-04-23 | FreiburgvM'gladbachBundesliga · Germany | 3–3 | Bundesliga · Germany |
| 2022-04-23 | Greuther FurthvLeverkusenBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-04-23 | Central CordobavBoca JuniorsCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-23 | PortimonensevMoreirensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-04-23 | TirolvRiedBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2022-04-23 | UralvUfaPremier League · Russia | 2–1 | Premier League · Russia |