| 2021-05-08 | AlavesvLevanteLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-05-08 | FiorentinavLazioSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-05-08 | AuxerrevGrenobleLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-05-08 | AltachvAustria ViennaBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-05-08 | Greuther FurthvKarlsruhe2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-05-08 | Guangzhou CityvShenzhenSuper League · China | 2–4 | Super League · China |
| 2021-05-08 | ElfsborgvKalmarAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-05-08 | Columbus CrewvDC UnitedMLS · United States | 3–1 | MLS · United States |
| 2021-05-08 | RizesporvYeni MalatyasporSüper Lig · Turkey | 0–4 | Süper Lig · Turkey |
| 2021-05-08 | Volos NFCvLarisaSuper League · Greece | 3–1 | Super League · Greece |
| 2021-05-08 | CadizvHuescaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-05-08 | SuttonvWeymouthNational League · England | 2–0 | National League · England |
| 2021-05-08 | SouthendvNewport CountyLeague Two · England | 1–1 | League Two · England |
| 2021-05-08 | GuingampvChateaurouxLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-05-08 | ScunthorpevStevenageLeague Two · England | 0–1 | League Two · England |
| 2021-05-08 | CarlislevWalsallLeague Two · England | 0–0 | League Two · England |
| 2021-05-08 | Lokomotiv MoscowvDynamo MoscowPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-05-08 | Bayern MunichvM'gladbachBundesliga · Germany | 6–0 | Bundesliga · Germany |
| 2021-05-08 | TroyesvDunkerqueLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-05-08 | Fortuna DusseldorfvBraunschweig2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-05-08 | St. PatricksvShamrock RoversPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2021-05-08 | HartbergvRiedBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-05-08 | PanetolikosvAtromitosSuper League · Greece | 1–3 | Super League · Greece |
| 2021-05-08 | BlackburnvBirminghamChampionship · England | 5–2 | Championship · England |
| 2021-05-08 | MorecambevBradfordLeague Two · England | 2–0 | League Two · England |
| 2021-05-08 | CoventryvMillwallChampionship · England | 6–1 | Championship · England |
| 2021-05-08 | LamiavOFI CreteSuper League · Greece | 0–2 | Super League · Greece |
| 2021-05-08 | ClermontvSochauxLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-05-08 | AdmiravSt. PoltenBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-05-08 | ToulousevCaenLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-05-08 | ExetervBarrowLeague Two · England | 1–1 | League Two · England |
| 2021-05-08 | HartlepoolvMaidenheadNational League · England | 2–4 | National League · England |
| 2021-05-08 | HataysporvDenizlisporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-05-08 | ChamblyvPau FCLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-05-08 | CSKA MoscowvKrasnodarPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-05-08 | LeedsvTottenhamPremier League · England | 3–1 | Premier League · England |
| 2021-05-08 | Atl. TucumanvDefensa y JusticiaCopa De La Liga Profesional · Argentina | 5–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-08 | PatronatovBoca JuniorsCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-08 | Gimnasia L.P.vVelez SarsfieldCopa De La Liga Profesional · Argentina | 0–5 | Copa De La Liga Profesional · Argentina |
| 2021-05-08 | Man CityvChelseaPremier League · England | 1–2 | Premier League · England |
| 2021-05-08 | BarnetvNotts CountyNational League · England | 1–4 | National League · England |
| 2021-05-08 | WatfordvSwanseaChampionship · England | 2–0 | Championship · England |
| 2021-05-08 | IntervSampdoriaSerie A · Italy | 5–1 | Serie A · Italy |
| 2021-05-08 | RodezvNancyLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-05-08 | Port ValevMansfieldLeague Two · England | 0–3 | League Two · England |
| 2021-05-07 | Akhmat GroznyvTambovPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-05-07 | Virtus EntellavChievoSerie B · Italy | 1–3 | Serie B · Italy |
| 2021-05-07 | OdensevAalborgSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-05-07 | CremonesevPescaraSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-05-07 | FamalicaovSanta ClaraPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |