| 2022-04-23 | Colon Santa FEvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-23 | RegensburgvHamburg2. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |
| 2022-04-23 | HamiltonvRaith RvsChampionship · Scotland | 0–2 | Championship · Scotland |
| 2022-04-23 | BirminghamvMillwallChampionship · England | 2–2 | Championship · England |
| 2022-04-23 | MalagavEibarLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2022-04-23 | NijmegenvAjaxEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-04-23 | St MirrenvHibernianPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2022-04-23 | Rosario CentralvIndependienteCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-23 | Holstein KielvHeidenheim2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-23 | Milton Keynes DonsvMorecambeLeague One · England | 2–0 | League One · England |
| 2022-04-23 | SunderlandvCambridgeLeague One · England | 5–1 | League One · England |
| 2022-04-23 | SwanseavMiddlesbroughChampionship · England | 1–1 | Championship · England |
| 2022-04-23 | SolihullvAldershotNational League · England | 2–1 | National League · England |
| 2022-04-23 | ClydevAirdrie UtdLeague One · Scotland | 0–5 | League One · Scotland |
| 2022-04-23 | BragantinovSao PauloSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2022-04-23 | Leyton OrientvNorthamptonLeague Two · England | 2–4 | League Two · England |
| 2022-04-23 | WiganvPlymouthLeague One · England | 1–1 | League One · England |
| 2022-04-23 | San LorenzovPatronatoCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-23 | IntervRomaSerie A · Italy | 3–1 | Serie A · Italy |
| 2022-04-23 | BrentfordvTottenhamPremier League · England | 0–0 | Premier League · England |
| 2022-04-23 | CartagenavGironaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2022-04-23 | PartickvDunfermlineChampionship · Scotland | 1–0 | Championship · Scotland |
| 2022-04-23 | PalmeirasvCorinthiansSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2022-04-23 | FluminensevInternacionalSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-04-23 | ArsenalvMan UnitedPremier League · England | 3–1 | Premier League · England |
| 2022-04-23 | VeneziavAtalantaSerie A · Italy | 1–3 | Serie A · Italy |
| 2022-04-23 | PueblavNecaxaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-23 | Notts CountyvWeymouthNational League · England | 3–1 | National League · England |
| 2022-04-23 | WaalwijkvZwolleEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2022-04-23 | CaenvAuxerreLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-23 | Queen of SthvAyrChampionship · Scotland | 1–1 | Championship · Scotland |
| 2022-04-23 | Man CityvWatfordPremier League · England | 5–1 | Premier League · England |
| 2022-04-23 | Boreham WoodvBromleyNational League · England | 2–0 | National League · England |
| 2022-04-23 | St Etiennev MonacoLigue 1 · France | 1–4 | Ligue 1 · France |
| 2022-04-23 | Ein FrankfurtvHoffenheimBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-04-23 | HJKvInter TurkuVeikkausliiga · Finland | 1–4 | Veikkausliiga · Finland |
| 2022-04-23 | StenhousemuirvStranraerLeague Two · Scotland | 1–3 | League Two · Scotland |
| 2022-04-23 | CharltonvShrewsburyLeague One · England | 2–0 | League One · England |
| 2022-04-23 | ChesterfieldvDover AthleticNational League · England | 3–2 | National League · England |
| 2022-04-23 | Bayern MunichvDortmundBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-04-23 | Paris SGvLensLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-04-23 | ExetervRochdaleLeague Two · England | 2–0 | League Two · England |
| 2022-04-23 | ElginvCowdenbeathLeague Two · Scotland | 1–4 | League Two · Scotland |
| 2022-04-23 | RotherhamvOxfordLeague One · England | 2–1 | League One · England |
| 2022-04-23 | IlvesvVPSVeikkausliiga · Finland | 3–2 | Veikkausliiga · Finland |
| 2022-04-23 | StromsgodsetvSandefjordEliteserien · Norway | 0–5 | Eliteserien · Norway |
| 2022-04-23 | GrimsbyvTorquayNational League · England | 2–1 | National League · England |
| 2022-04-23 | SouthendvHalifaxNational League · England | 1–0 | National League · England |
| 2022-04-23 | BradfordvScunthorpeLeague Two · England | 2–1 | League Two · England |
| 2022-04-23 | YeovilvStockportNational League · England | 2–1 | National League · England |