| 2021-05-08 | HammarbyvSiriusAllsvenskan · Sweden | 3–2 | Allsvenskan · Sweden |
| 2021-05-08 | AZ AlkmaarvFor SittardEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-05-08 | Shandong TaishanvQingdao FCSuper League · China | 2–0 | Super League · China |
| 2021-05-08 | LyonvLorientLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-05-08 | Nott'm ForestvPrestonChampionship · England | 1–2 | Championship · England |
| 2021-05-08 | PodbeskidzievWisla PlockEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-05-08 | Wurzburger KickersvOsnabruck2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2021-05-08 | Sagan TosuvSanfrecce HiroshimaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-05-08 | Orlando CityvNew York CityMLS · United States | 1–1 | MLS · United States |
| 2021-05-08 | BohemiansvFinn HarpsPremier Division · Ireland | 4–0 | Premier Division · Ireland |
| 2021-05-08 | HalifaxvBoreham WoodNational League · England | 0–1 | National League · England |
| 2021-05-08 | DortmundvRB LeipzigBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-05-08 | ReadingvHuddersfieldChampionship · England | 2–2 | Championship · England |
| 2021-05-08 | Ath BilbaovOsasunaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-05-08 | VVV VenlovWaalwijkEredivisie · Netherlands | 3–3 | Eredivisie · Netherlands |
| 2021-05-08 | WrexhamvYeovilNational League · England | 3–0 | National League · England |
| 2021-05-08 | UfavZenitPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-05-08 | BournemouthvStokeChampionship · England | 0–2 | Championship · England |
| 2021-05-08 | TwentevHeraclesEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-05-08 | GoztepvKonyasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-05-08 | MiddlesbroughvWycombeChampionship · England | 0–3 | Championship · England |
| 2021-05-08 | AmiensvNiortLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-05-08 | Nagoya GrampusvCerezo OsakaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-05-08 | NantesvBordeauxLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-05-08 | BarnsleyvNorwichChampionship · England | 2–2 | Championship · England |
| 2021-05-08 | WislavLech PoznanEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-05-08 | Gaz Metan MediasvAstraSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-05-08 | GalatasarayvBesiktasSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-05-08 | ZaragozavEspanolLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-05-08 | QPRvLutonChampionship · England | 3–1 | Championship · England |
| 2021-05-08 | Lechia GdanskvCracoviaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-05-08 | Bristol CityvBrentfordChampionship · England | 1–3 | Championship · England |
| 2021-05-08 | MalagavMallorcaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-05-08 | AjacciovParis FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-05-08 | HoffenheimvSchalke 04Bundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2021-05-08 | PonferradinavAlbaceteLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-05-08 | Crawley TownvBoltonLeague Two · England | 1–4 | League Two · England |
| 2021-05-08 | ValenciennesvLe HavreLigue 2 · France | 3–5 | Ligue 2 · France |
| 2021-05-08 | AnkaragucuvFenerbahceSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-05-08 | Nashville SCvNew England RevolutionMLS · United States | 2–0 | MLS · United States |
| 2021-05-08 | Sheffield UnitedvCrystal PalacePremier League · England | 0–2 | Premier League · England |
| 2021-05-08 | HeerenveenvUtrechtEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-05-08 | SivassporvBuyuksehyrSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-05-08 | DerbyvSheffield WedsChampionship · England | 3–3 | Championship · England |
| 2021-05-08 | CheltenhamvHarrogateLeague Two · England | 4–1 | League Two · England |
| 2021-05-08 | Gamba OsakavKawasaki FrontaleJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-05-08 | SalfordvLeyton OrientLeague Two · England | 3–0 | League Two · England |
| 2021-05-08 | GoteborgvHackenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-08 | WealdstonevDag and RedNational League · England | 0–5 | National League · England |
| 2021-05-08 | TrabzonsporvAntalyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |