| 2022-04-24 | Dundee UnitedvHeartsPremiership · Scotland | 2–3 | Premiership · Scotland |
| 2022-04-24 | ChelseavWest HamPremier League · England | 1–0 | Premier League · England |
| 2022-04-24 | AntalyasporvKayserisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-04-24 | Portland TimbersvReal Salt LakeMLS · United States | 0–0 | MLS · United States |
| 2022-04-24 | VikingvBodo/GlimtEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2022-04-24 | BuyuksehyrvHataysporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2022-04-24 | Guadalajara ChivasvUNAM PumasLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2022-04-24 | Rubin KazanvArsenal TulaPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-04-24 | NordsjaellandvViborgSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2022-04-24 | A. KlagenfurtvWolfsberger ACBundesliga · Austria | 2–3 | Bundesliga · Austria |
| 2022-04-24 | Colorado RapidsvCharlotteMLS · United States | 0–0 | MLS · United States |
| 2022-04-24 | MetzvBrestLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-04-24 | GrasshoppersvLausanneSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2022-04-24 | AarhusvOdenseSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2022-04-24 | PaderbornvHannover2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-04-24 | Cruz AzulvAtl. San LuisLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-24 | NurnbergvSandhausen2. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |
| 2022-04-24 | LillestromvHaugesundEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2022-04-24 | TromsovSarpsborg 08Eliteserien · Norway | 2–5 | Eliteserien · Norway |
| 2022-04-24 | Lech PoznanvStal MielecEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2022-04-24 | AltayvGalatasaraySüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2022-04-24 | St. GallenvLuganoSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2022-04-24 | For SittardvGo Ahead EaglesEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-04-24 | BochumvAugsburgBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-04-24 | San Jose EarthquakesvSeattle SoundersMLS · United States | 4–3 | MLS · United States |
| 2022-04-24 | Erzgebirge AuevHansa Rostock2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-04-24 | Willem IIvVitesseEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-04-24 | FeyenoordvUtrechtEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-04-24 | New York CityvToronto FCMLS · United States | 5–4 | MLS · United States |
| 2022-04-24 | BaselvLuzernSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2022-04-24 | FC CincinnativLos Angeles FCMLS · United States | 1–2 | MLS · United States |
| 2022-04-24 | NicevTroyesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-04-24 | FC VoluntarivCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-04-24 | Los Angeles GalaxyvNashville SCMLS · United States | 1–0 | MLS · United States |
| 2022-04-24 | HelsingborgvHackenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2022-04-24 | RosenborgvMoldeEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2022-04-24 | BanfieldvTalleres CordobaCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-24 | Ross CountyvCelticPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2022-04-23 | Cove RangersvDumbartonLeague One · Scotland | 1–0 | League One · Scotland |
| 2022-04-23 | ZurichvSionSuper League · Switzerland | 5–1 | Super League · Switzerland |
| 2022-04-23 | MontrosevQueens ParkLeague One · Scotland | 2–1 | League One · Scotland |
| 2022-04-23 | AdmiravHartbergBundesliga · Austria | 1–3 | Bundesliga · Austria |
| 2022-04-23 | Schalke 04vWerder Bremen2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |
| 2022-04-23 | Gimnasia L.P.vUnion de Santa FeCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-23 | HarrogatevCarlisleLeague Two · England | 3–0 | League Two · England |
| 2022-04-23 | AltrinchamvWealdstoneNational League · England | 4–2 | National League · England |
| 2022-04-23 | Sheffield UnitedvCardiffChampionship · England | 1–0 | Championship · England |
| 2022-04-23 | PeterborovNott'm ForestChampionship · England | 0–1 | Championship · England |
| 2022-04-23 | Gil VicentevPacos FerreiraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-04-23 | AccringtonvLincolnLeague One · England | 2–1 | League One · England |