| 2021-05-09 | Willem IIvPSV EindhovenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-05-09 | UTA AradvPoli IasiSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-05-09 | CharltonvHullLeague One · England | 1–0 | League One · England |
| 2021-05-09 | SunderlandvNorthamptonLeague One · England | 1–1 | League One · England |
| 2021-05-09 | West HamvEvertonPremier League · England | 0–1 | Premier League · England |
| 2021-05-09 | Pacos FerreiravMaritimoPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-05-09 | CangzhouvGuangzhou FCSuper League · China | 0–2 | Super League · China |
| 2021-05-09 | LincolnvAFC WimbledonLeague One · England | 0–0 | League One · England |
| 2021-05-09 | Chongqing Liangjiang AthleticvHenan Songshan LongmenSuper League · China | 3–2 | Super League · China |
| 2021-05-09 | Shonan BellmarevOita TrinitaJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-05-09 | CrewevShrewsburyLeague One · England | 3–2 | League One · England |
| 2021-05-09 | Los Angeles GalaxyvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2021-05-09 | CartagenavCastellonLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-09 | Santos LagunavQueretaroLiga MX · Mexico | 5–0 | Liga MX · Mexico |
| 2021-05-09 | Randers FCvAarhusSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-05-09 | St. GallenvSionSuper League · Switzerland | 0–3 | Super League · Switzerland |
| 2021-05-09 | PanathinaikosvAEKSuper League · Greece | 0–1 | Super League · Greece |
| 2021-05-09 | IpswichvFleetwood TownLeague One · England | 3–1 | League One · England |
| 2021-05-09 | VeronavTorinoSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-09 | LuzernvServetteSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2021-05-09 | LogronesvGironaLa Liga 2 · Spain | 1–4 | La Liga 2 · Spain |
| 2021-05-09 | HeidenheimvSandhausen2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-05-08 | KayserisporvGaziantepSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-05-08 | Chicago FirevPhiladelphia UnionMLS · United States | 0–2 | MLS · United States |
| 2021-05-08 | LuganovVaduzSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2021-05-08 | OrebrovHalmstadAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-05-08 | WaterfordvDroghedaPremier Division · Ireland | 0–7 | Premier Division · Ireland |
| 2021-05-08 | Real Salt LakevSan Jose EarthquakesMLS · United States | 1–2 | MLS · United States |
| 2021-05-08 | WokingvChesterfieldNational League · England | 1–4 | National League · England |
| 2021-05-08 | FC DallasvHouston DynamoMLS · United States | 1–1 | MLS · United States |
| 2021-05-08 | New York Red BullsvToronto FCMLS · United States | 2–0 | MLS · United States |
| 2021-05-08 | AlcorconvLas PalmasLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-05-08 | Godoy CruzvBanfieldCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-08 | SpeziavNapoliSerie A · Italy | 1–4 | Serie A · Italy |
| 2021-05-08 | LiverpoolvSouthamptonPremier League · England | 2–0 | Premier League · England |
| 2021-05-08 | Young BoysvBaselSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-05-08 | CardiffvRotherhamChampionship · England | 1–1 | Championship · England |
| 2021-05-08 | Vancouver WhitecapsvCF MontrealMLS · United States | 2–0 | MLS · United States |
| 2021-05-08 | Arsenal TulavRubin KazanPremier League · Russia | 2–4 | Premier League · Russia |
| 2021-05-08 | WolfsburgvUnion BerlinBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-05-08 | Din. BucurestivFC HermannstadtSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-05-08 | TranmerevColchesterLeague Two · England | 0–0 | League Two · England |
| 2021-05-08 | OldhamvForest GreenLeague Two · England | 0–3 | League Two · England |
| 2021-05-08 | TorquayvBromleyNational League · England | 0–0 | National League · England |
| 2021-05-08 | CambridgevGrimsbyLeague Two · England | 3–0 | League Two · England |
| 2021-05-08 | UdinesevBolognaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-08 | Werder BremenvLeverkusenBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-05-08 | Erzurum BBvKasimpasaSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-05-08 | KaragumrukvGenclerbirligiSüper Lig · Turkey | 5–1 | Süper Lig · Turkey |
| 2021-05-08 | BarcelonavAth MadridLa Liga · Spain | 0–0 | La Liga · Spain |